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Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the identified somatic mutations in 94 T-cell acute lymphoblastic leukaemia cases. ETP ALL was characterized by activating mutations in genes regulating(More)
Let R n be the ring of coinvariants for the diagonal action of the symmetric group S n. It is known that the character of R n as a doubly-graded S n module can be expressed using the Frobenius characteristic map as ∇e n , where e n is the n-th elementary symmetric function, and ∇ is an operator from the theory of Macdonald polynomials. We conjecture a(More)
Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known. Here we show that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated. To identify(More)
A smooth compactification Xn of configuration spaces of n distinct labeled points in a smooth algebraic variety X is constructed by a natural sequence of blowups. The full symmetry of the permutation group Sn is manifest at each stage of the construction. There is a strata-compatible surjection onto the Fulton–MacPherson compactifica-tion. The strata of the(More)
Retinoblastoma is a childhood cancer of the developing retina that begins in utero and is diagnosed in the first years of life. Biallelic RB1 gene inactivation is the initiating genetic lesion in retinoblastoma. The p53 gene is intact in human retinoblastoma but the pathway is believed to be suppressed by increased expression of MDM4 (MDMX) and MDM2. Here(More)
BACKGROUND Gecko (Gene Expression: Computation and Knowledge Organization) is a complete, high-capacity centralized gene expression analysis system, developed in response to the needs of a distributed user community. RESULTS Based on a client-server architecture, with a centralized repository of typically many tens of thousands of Affymetrix scans, Gecko(More)
It was found that 3-fold intranasal administration of Arg-Pro-Gly-Pro peptide in a dose of 1 mg/kg body weight under conditions of experimental persistent hyperglycemia prevents the development of diabetes in experimental rats and produces normoglycemic, anticoagulant, fibrinolytic, and antiplatelet effects.
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