Anatoly Ulyanov

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Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the identified somatic mutations in 94 T-cell acute lymphoblastic leukaemia cases. ETP ALL was characterized by activating mutations in genes regulating(More)
Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known. Here we show that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated. To identify(More)
Retinoblastoma is a childhood cancer of the developing retina that begins in utero and is diagnosed in the first years of life. Biallelic RB1 gene inactivation is the initiating genetic lesion in retinoblastoma. The p53 gene is intact in human retinoblastoma but the pathway is believed to be suppressed by increased expression of MDM4 (MDMX) and MDM2. Here(More)
A smooth compactification X〈n〉 of configuration spaces of n distinct labeled points in a smooth algebraic variety X is constructed by a natural sequence of blowups. The full symmetry of the permutation group Sn is manifest at each stage of the construction. There is a strata-compatible surjection onto the Fulton–MacPherson compactification. The strata of(More)
Gecko (Gene Expression: Computation and Knowledge Organization) is a complete, high-capacity centralized gene expression analysis system, developed in response to the needs of a distributed user community. Based on a client-server architecture, with a centralized repository of typically many tens of thousands of Affymetrix scans, Gecko includes automatic(More)
135 It was shown earlier that the regulatory peptides Pro–Gly, Pro–Gly–Pro [1], Phe–Pro–Gly–Pro [1⎯4], Pro–Gly–Pro–Leu [5], Pro–Gly–Pro–Arg, Pro–Gly–Arg [6] have both protective and therapeu tic effects on the development of insulin dependent alloxan diabetes mellitus (IDDM). During IDDM development the functional activity of the anticoagu lative system(More)
AMOEBOID OLIVINE AGGREGATES FROM EFREMOVKA (CV3). S. S. Russell, A. N. Krot, T. E. Jeffries, and A. A. Ulyanov Dept. Mineralogy, The Natural History Museum, Cromwell Road, London SW7 5BD, UK ( Hawai’i Institute of Geophysics and Planetology, School of Ocean and Earth Science and Technology, Universitry of Hawai’i at Manoa, Honolulu, HI 96822,(More)
A temporary resistance to the hypoglycaemic action of insulin has been found after preliminary binding of heparin in the blood of animals by 1 mg/200 of protamine sulphate (PS). This effect was observed after 5-30 min PS treatment before the insulin injection or endogenous increase of insulin stimulated by sugar load. PS did not influence the concentration(More)