Breast cancer is the most commonly diagnosed cancer in women and the number two cause of cancer associated death. Surgery is the first line of defense in treating breast cancer and the success of surgery has been shown to predict the probability of cancer reoccurrence. Near Infrared (NIR) fluorescence guided surgery offers the potential to increase the… (More)
BACKGROUND Secoisolariciresinol diglucoside (SDG), the main lignan in whole grain flaxseed, is a potent antioxidant and free radical scavenger with known radioprotective properties. However, the exact mechanism of SDG radioprotection is not well understood. The current study identified a novel mechanism of DNA radioprotection by SDG in physiological… (More)
We report a reaction of direct electrophilic fluorination of phenolsulfonphthalein at mild conditions. This reaction affords the synthesis of novel positron-emitting 18F-labeled pH indicators. These compounds are useful for non-invasive in vivo pH measurement in biological objects.