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IL-6/IL-6R axis plays a critical role in acute kidney injury.
The response to tissue injury involves the coordination of inflammatory and repair processes. IL-6 expression correlates with the onset and severity of acute kidney injury (AKI), but its contributionExpand
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Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation.
BACKGROUND & AIMS Interleukin-6 (IL-6) is a crucial factor in liver regeneration following partial hepatectomy (PH); however, the role of IL-6 and IL-6 trans-signaling in particular, in hepatocyteExpand
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In vivo evidence suggesting reciprocal renal hypoxia‐inducible factor‐1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non‐hypoxic stimuli
In vitro studies suggest that combined activation of hypoxia‐inducible factor (HIF) and signal transducer and activator of transcription 3 (STAT3) promotes the hypoxia response. However, theirExpand
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Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis
Liver cancer, which typically develops on a background of chronic liver inflammation, is now the second leading cause of cancer mortality worldwide. For patients with liver cancer, surgical resectionExpand
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Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker
BackgroundAlthough lymph node-positive breast cancers are associated with poorer prognosis, individual patients may have different clinical outcomes. Signal transducer and activator of transcriptionExpand
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JX401, A p38α Inhibitor Containing a 4-Benzylpiperidine Motif, Identified via a Novel Screening System in Yeast
In vivo screening of compounds for potential pharmacological activity is more advantageous than in vitro screening. In vivo screens eliminate the isolation of compounds that cannot cross biologicalExpand
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IL6-dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis
1 Goldyne Savad Institute of Gene Therapy, 2 Sharett Institute of Oncology; and 3 Magnetic Resonance Imaging/Magnetic Resonance Spectroscopy Laboratory, Human Biology Research Center, and 4 InstitutExpand
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Formation mechanism of gold-based and gold-free ohmic contacts to AlGaN/GaN heterostructure field effect transistors
To better understand the formation mechanism of ohmic contacts to GaN-based heterostructure field effect transistors, we have compared in detail Ti/Al/Ti/Au and Ti/Al/Ti/TiN contacts. TransmissionExpand
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The influence of carbon doping on the performance of Gd2O3 as high-k gate dielectric
One of the approaches for overcoming the issue of leakage current in modern metal-oxide-semiconductor devices is utilizing the high dielectric constants of lanthanide based oxides. We investigatedExpand
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Inhibiteurs de la kinase p38-$g(a)
L'invention concerne des composes permettant d'inhiber la kinase p38α, des compositions pharmaceutiques comprenant ces composes, et des methodes d'utilisation de ces composes destinees a traiter ou aExpand