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Opioids modulate constitutive B-lymphocyte secretion.
The opioid system plays a major role in immunomodulation, while its action on cells of the immune system may be opioid receptor-mediated or not. Opioid effects on B-lymphocytes are considered asExpand
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Opioids increase bladder cancer cell migration via bradykinin B2 receptors.
Data relating opioid treatment and modification of cancer cell migration (a prerequisite of metastasis) both in vitro and in vivo are diverging. In the present report we show that opioids increaseExpand
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Sphingosine 1-phosphate signaling through its receptor S1P5 promotes chromosome segregation and mitotic progression
Targeting the signaling lipid S1P might suppress tumor growth by slowing mitosis. Sphingolipids stimulate mitosis Drugs that attempt to halt the increased rate of cell division or mitosis in tumorsExpand
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Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis.
Gem is a small guanosine triphosphate (GTP)-binding protein within the Ras superfamily, involved in the regulation of voltage-gated calcium channel activity and cytoskeleton reorganization. GemExpand
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Development and characterization of sphingosine 1-phosphate receptor 1 monoclonal antibody suitable for cell imaging and biochemical studies of endogenous receptors
Although sphingosine-1-phosphate receptor 1 (S1P1) has been shown to trigger several S1P targeted functions such as immune cell trafficking, cell proliferation, migration, or angiogenesis, tools thatExpand
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La sclérose en plaques et les médicaments immuno-modulateurs des récepteurs de la sphingosine 1-phosphate
La sclerose en plaques (SEP) est une maladie du systeme nerveux central a composante inflammatoire, tres invalidante qui atteint generalement de jeunes adultes (20 a 40 ans). Cette maladie seExpand
Sphingosine 1-Phosphate signaling controls mitosis
Besides their structural role, sphingolipids including Sphingosine-1phosphate (S1P) have drawn attention as bioactive sphingolipid signaling molecules involved in the regulation of several processes,Expand
[Multiple sclerosis and immuno-modulators of sphingosine 1-phosphate receptors].
Multiple sclerosis (MS) is a disease of the central nervous system with a very debilitating inflammatory component that usually affects young people (years 20-40). This disease is characterized byExpand