Anastasiya Smirnova

We don’t have enough information about this author to calculate their statistics. If you think this is an error let us know.
Learn More
1. TRH and A-1 shorten the duration of sleep. 2. A-2 promoted an earlier onset of sleep and increased its individual phases. 3. TRH and A-1 had marked antagonistic effects on nembutal toxicity. 4. TRH analogs (A-1 and A-2) did not influence TTH secretion by the hypophysis. TRH and A-1 shorten the duration of sleep. A-2 promoted an earlier onset of sleep and(More)
1. A-3, a TRH analogue, accelerates the time of onset of slow sleep and prolongs the duration of the deep slow sleep phase. 2. The TRH analogue investigated decreases the inhibiting action of slow sleep on the respiration frequency. A-3, a TRH analogue, accelerates the time of onset of slow sleep and prolongs the duration of the deep slow sleep phase. The(More)
i. I. S. Morozov, Farmakol. Toksikol., No. ,5, 540 (1980). 2. I. S. Morozov and D. D. Pukhov, Byull. Eksp. Biol. Med., No. i0, 500 (1979). 3. I. S. Morozov and G. S. Pukhova, in: Pharmacological Regulation of Fatigue Processes [in Russian], Moscow (1982), p. 102. 4. G. S. Pukhova, I. S. Morozov, and E. R. Ivanov, Uch. Zap. Tartu. Univ., No. 606, 148 (1982).(More)
An analysis and experimental evaluation of various pathways for the synthesis of tripeptidamide I showed that a promising method is offered by a solution synthesis using the 2 + 1 scheme. Based on this approach, we have developed an effective procedure for the complete chemical synthesis of L-pyroglutamyl-L-seryl-D-leucine isopropylamide (I). A(More)
TRH and its two analogs with modified hormonal activity were examined for the capacity to antagonize acute and chronic effects of ethanol in mice. It has been demonstrated that L-pyroglutamyl-L-seryl-L-leucinamide, an analog of TRH, that does not affect the secretion of TSH and decreases prolactin production has the same capacity as TRH to reduce the time(More)
The synthesis of retro-analog of methionine-5-enkephalin was performed. This peptide is an isomer of the natural methionine-5-enkephalin, but differs from it by opposite direction of peptide linkages between the amino acid residues. The influence of retro-analog on prolactin secretion was studied both in vivo and in vitro. The retro-analog was found to(More)
No. 2, 439 (1972). Shevchenko, Yu. G., Evolution of the Cerebral Cortex of Primates and Man [in Russian], Moscow University Press, Moscow (1971), p. 463. Shustin, N. A., "On some common functions of the corpora striata and frontal lobes of the cerebral hemispheres," in: The Basal Ganglia and Behavior [in Russian], Leningrad (1972), pp. 80-82. Sidyakin, V.(More)
In the course of investigation of the quantitative relationship between chemical structure and biological activity of the peptide bioregulators of prolactin secretion, we have synthesized a series of previously unreported structural analogs of thyroliberin [1 – 3]. The new compounds (I and II) differ from the natural hormone by single-point replacements of(More)