We present a new method for parameter identification of ODE system descriptions based on data measurements. Our method works by splitting the system into a number of subsystems and working on each of them separately, thereby being easily parallelisable, and can also deal with noise in the observations.
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We present a software tool for the automatic translation of models from the Narrative Language, a semi-formal language for biological modelling, into the Bio-PEPA process algebra. This provides biologists with an easy way to describe systems and at the same time gives them access to the simulation and analysis techniques provided by Bio-PEPA. We present… (More)
We present two process algebra models of a Kai-protein based circadian clock. Our models are represented in the Bio-PEPA and the continuous pi-calculus process algebras. The circadian clock is not based on transcription and has been shown to persist with a rhythmic signal when removed from a living cell. Our models allow us to speculate as to the mechanisms… (More)