Anastasios Bonakis

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BACKGROUND Conversely to other neurodegenerative diseases (i.e., Alzheimer's disease, AD), sleep in frontotemporal dementia (FTD) has not been studied adequately. Although some evidence exists that sleep-wake disturbances occur in FTD, very little is known regarding sleep macrostructure and/or primary sleep disorders. OBJECTIVE To investigate these issues(More)
Although daytime sleepiness is commonly associated with obstructive sleep apnoea (OSA), the relationship between OSA severity and subjective sleepiness has been documented elusive. This study aimed to identify clinical and polysomnographic determinants of subjective sleepiness among patients suspected of having OSA. A sleep clinic-based sample of 915(More)
The Stroop Test is a quick and frequently used measure in screening for brain damage, dysfunction of selective attention, and cognitive flexibility. The purpose of the present study is to provide normative data for Trenerry's Stroop Neuropsychological Screening Test (SNST) in a sample of 605 healthy Greek participants (age range: 18-84 years, education(More)
Paraneoplastic cerebellar degeneration (PCD) is a rare neurological complication of non-metastatic malignancy. Usually its clinical manifestation is that of subacute ataxia, dysarthria and nystagmus. Here we present a case of PCD of acute onset in a patient with ovarian carcinoma. A 56-year-old woman was admitted in our department with gait ataxia and(More)
STUDY OBJECTIVES To retrospectively examine the characteristics of a population of patients <50 years of age with clinical and polysomnographic features diagnostic for RBD. METHODS Review of our sleep centre's database for patients with RBD diagnosed over the last 7 years. Ninety-one patients were separated into two groups according to their age at the(More)
OBJECTIVE To investigate the frequency and causes of early-onset dementia (EOD) in consecutive patients in a highly specialized dementia referral center, focusing on unusual cases, particularly with early and/or rapid onset, in Athens, Greece. METHODS Patients referred for dementia diagnosis according to specific referral criteria during a 3 years period.(More)
BACKGROUND Cerebrospinal fluid (CSF) biomarkers have been increasingly studied in dementia clinical and differential diagnosis. METHODS We assessed levels of total tau protein (tauT), tau phosphorylated at threonine 181 (tau P-181), and beta-amyloid1-42 (A beta 42) in 34 patients with frontotemporal lobar degeneration (FTLD), 76 Alzheimer disease (AD)(More)
Sirs: The association of chorea and motor neuron disease is extremely rare in clinical practice [1] and was initially reported by Fotopoulos in 1966 [2]. Here we report a case of late onset, genetically confirmed Huntington’s disease (HD) and sporadic amyotrophic lateral sclerosis (ALS) that appeared concomitantly. A 72-year-old woman presented with(More)
The case of a 76-year-old female patient is presented with a two-year history of progressive dementia, apathy and gait impairment. Initially, Alzheimer's disease was diagnosed and she was given donepezil for one year with no significant improvement. An extensive blood and biochemical control revealed high serum calcium and parathormone levels, and normal(More)
The time-varying microstructure of sleep EEG spindles may have clinical significance in dementia studies and can be quantified with a number of techniques. In this paper, real and simulated sleep spindles were regarded as AM/FM signals modeled by six parameters that define the instantaneous envelope (IE) and instantaneous frequency (IF) waveforms for a(More)