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Directed evolution relies on iterative cycles of randomization and selection. The outcome of an artificial evolution experiment is crucially dependent on (i) the numbers of variants that can be screened and (ii) the quality of the assessment of each clone that forms the basis for selection. Compartmentalization of screening assays in water-in-oil emulsion(More)
The success of a directed evolution approach to creating custom-made enzymes relies in no small part on screening as many clones as possible. The miniaturisation of assays into pico to femtoliter compartments (emulsion droplets, vesicles or gel-shell beads) makes directed evolution campaigns practically more straightforward than current large scale(More)
The direct CP violation parameter Re(ε ′ /ε) has been measured from the decay rates of neutral kaons into two pions using the NA48 detector at the CERN SPS. With 3.3 million KL → π 0 π 0 events collected during the 1998 and 1999 running periods, a result of Re(ε ′ /ε) = (15.0 ± 2.7)×10 −4 has been obtained. The result combined with the published 1997 sample(More)
The direct CP violation parameter Re((//) has been measured from the decay rates of neutral kaons into two pions using the NA48 detector at the CERN SPS. The 2001 running period was devoted to collecting additional data under varied conditions compared to earlier years (1997–1999). The new data yield the result: Re((//) = (13.7 ± 3.1) × 10 −4. Combining(More)
The characteristics of immune responsiveness were studied in 455 children aged 2 months to 14 years with the generalized forms of meningococcal infection. In children of all age groups an increase in the titers of antibodies to meningococci was revealed; this increase started from day 4 of the disease, reached its maximum at the end of week 3 or the(More)
The results of the use of the two new methods for early diagnosis of herpes simplex virus infection based on immuno-mediated hemagglutination and hemadsorption are presented. In these methods, staphylococcal diagnostic preparations with two kinds of adsorbed antibody are used which allow the presence of the virus to be detected and simultaneously(More)
A value of (−6.1 ± 0.9 stat ± 0.5 syst) × 10 −3 is obtained for the quadratic slope parameter h in the K L → 3π 0 decay Dalitz plot at the NA48 experiment at the CERN SPS. The result is based on 14.7 × 10 6 fully reconstructed K L → 3π 0 → 6γ decays. This is the most precise measurement of any of the Dalitz plot slope parameters in the charged and neutral(More)