Anastasia Osokina

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A T-to-C substitution, replacing a hydrophobic isoleucine residue with a hydrophilic threonine residue in position 100 of a mature protein molecule, was found at codon 117 of the GM-CSF gene. The mutation frequencies were estimated in 51 DNA samples from healthy adult donors and also in 20 samples from patients with different neoplastic myeloid disorders.(More)
We measured levels of several parameters of immune inflammation (interleukins [IL] 1, 6, 8, 10, 12, tumor necrosis factor [TNF], serum neopterin, C-reactive protein) on days 10-14 after onset of ST segment elevation myocardial infarction (MI) and related them to results of 12 months follow up. Elevated titers of IL-12 and neopterin were significantly(More)
AIM To identify predictors of contrast-induced nephropathy (CIN) and evaluate its significance for the hospital prognosis of myocardial infarction with elevated ST segment. MATERIALS AND METHODS 722 (75.7%) of the total 954 patients underwent X ray examination with the use of contrast material (coronary angiography (CAG) and/or transcutaneous coronary(More)
BACKGROUND Patients with myocardial infarction (MI) have a high mortality. Therefore, new risk markers and predictors of an adverse outcome for MI are required. The role of hyperglycemia in the development of cardiovascular complications in MI patients is still unclear. METHODS A total of 529 consecutive patients with the diagnosis of ST-segment elevation(More)
This study aimed to evaluate the association between serum galectin levels and renal dysfunction in relation to in-hospital prognosis and unfavorable prognosis 1 year after ST-elevated myocardial infarction (STEMI). Patients were assigned to two groups according to the cystatin C-based estimate of GFR on day 12 after STEMI: (1) STEMI patients with normal(More)
AIM To make a prediction scale using a set of clinical and laboratory prognostic variables for patients with ST-segment elevation myocardial infarction (STEMI) on their electrocardiograms (ECG) who have undergone percutaneous coronary intervention. SUBJECTS AND METHODS The study enrolled 154 STEMI patients who had undergone percutaneous coronary(More)
We aimed to assess the clinical significance of serum levels of neutrophil gelatinase-associated lipocalin (sNGAL) for predicting in-hospital outcomes in patients with ST-elevated myocardial infarction (STEMI). Patients admitted within 24 hours of developing STEMI clinical symptoms were evaluated for sNGAL on hospitalization days 1 and 12. Recurrent(More)
AIM to assess value for inhospital and 1 year prognosis of unfavorable course of ST-elevation myocardial infarction (STEMI) of blood serum galectin and markers of renal dysfunction (RD). MATERIAL AND METHODS Standard laboratory and instrumental examination, calculation of glomerular filtration rate using MDRD formula and by cystatin C level, determination(More)
Preclinical study of the safety of arhem (heme arginate), a new drug intended for the treatment of porphyrin metabolism disorders, has been performed. Arhem proved to be a nontoxic preparation with a large therapeutic margin (high ratio of the toxic dose to effective dose). Even during long-term administration at high doses, arhem does not affect most(More)
AIM To comparatively assess formulas for estimating glomerular filtration rate (GFR) in the prediction of poor outcomes in patients with type 2 diabetes mellitus (DM) within one year after myocardial infarction (MI). MATERIALS AND METHODS The investigators examined 89 patients with ST-segment elevation myocardial infarction (STEMI) within 24 hours after(More)