Anastasia C Weeks

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PURPOSE To determine the effectiveness of moxifloxacin and besifloxacin prophylactic therapy for experimental Staphylococcus aureus infections originating in the rabbit anterior chamber. SETTING Microbiology Department, University of Mississippi Medical Center, Jackson, Mississippi, USA. DESIGN Experimental study. METHODS Minimum inhibitory(More)
PURPOSE To determine the virulence of Staphylococcus aureus strains in the rabbit conjunctiva. METHODS Three strains of methicillin-sensitive S. aureus (8325-4, Newman, and UMCR1) and two strains of methicillin-resistant S. aureus (70490 and MW2) were analyzed. Rabbit bulbar conjunctivas (n ≥ 6 per group) were injected with 10(5) colony forming units(More)
PURPOSE Staphylococcus aureus, a leading cause of bacterial keratitis, secretes α-toxin, a cytotoxin active on the corneal epithelium. This study describes the production and testing of chemical inhibitors of α-toxin action. METHODS Purified α-toxin was titered by its ability to lyse rabbit erythrocytes in buffered saline (PBS). To prepare potential toxin(More)
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