• Publications
  • Influence
Atypical Mechanism of Regulation of the Wrch-1 Rho Family Small GTPase
Rho family GTPases are GDP/GTP-regulated molecular switches that regulate signaling pathways controlling diverse cellular processes. Wrch-1 was identified as a Wnt-1 regulated Cdc42 homolog,Expand
  • 84
  • 15
Transforming Activity of the Rho Family GTPase, Wrch-1, a Wnt-regulated Cdc42 Homolog, Is Dependent on a Novel Carboxyl-terminal Palmitoylation Motif*
Wrch-1 is a Rho family GTPase that shares strong sequence and functional similarity with Cdc42. Like Cdc42, Wrch-1 can promote anchorage-independent growth transformation. We determined thatExpand
  • 83
  • 8
Biochemical analyses of the Wrch atypical Rho family GTPases.
The Rho family of GTPases comprises a major branch of the Ras superfamily of small GTPases. To date, at least 22 human members have been identified. However, most of our knowledge of Rho GTPaseExpand
  • 29
  • 6
Regulation of the Rho Family Small GTPase Wrch-1/RhoU by C-Terminal Tyrosine Phosphorylation Requires Src
ABSTRACT Wrch-1 is an atypical Rho family small GTPase with roles in migration, epithelial cell morphogenesis, osteoclastogenesis, and oncogenic transformation. Here, we observed rapid relocalizationExpand
  • 37
  • 5
Using inhibitors of prenylation to block localization and transforming activity.
The proper subcellular localization and biological activity of most Ras and Rho family small GTPases are dependent on their posttranslational modification by isoprenylation. FarnesyltransferaseExpand
  • 34
  • 1
Visual monitoring of post-translational lipid modifications using EGFP-GTPase probes in live cells.
Modification of small GTPases by lipids is required for their proper subcellular localization and biological activity. Lipids added post-translationally include both farnesyl and geranylgeranylExpand
  • 9