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Biochemical analyses of the Wrch atypical Rho family GTPases.

• Adam Shutes, Anastacia C. Berzat, Emily Chenette, Adrienne D Cox, Channing J Der
• Methods in enzymology
• 2006

The Rho family of GTPases comprises a major branch of the Ras superfamily of small GTPases. To date, at least 22 human members have been identified. However, most of our knowledge of Rho GTPase… (More)

Atypical Mechanism of Regulation of the Wrch-1 Rho Family Small GTPase

• Adam Shutes, Anastacia C. Berzat, Adrienne D Cox, Channing J Der
• Current Biology
• 2004

Rho family GTPases are GDP/GTP-regulated molecular switches that regulate signaling pathways controlling diverse cellular processes. Wrch-1 was identified as a Wnt-1 regulated Cdc42 homolog,… (More)

Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif.

• Anastacia C. Berzat, Janice E. Buss, +5 authors Adrienne D Cox
• The Journal of biological chemistry
• 2005

Wrch-1 is a Rho family GTPase that shares strong sequence and functional similarity with Cdc42. Like Cdc42, Wrch-1 can promote anchorage-independent growth transformation. We determined that… (More)

Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src.

• Jamie K Alan, Anastacia C. Berzat, Brian J. Dewar, Lee M Graves, Adrienne D Cox
• Molecular and cellular biology
• 2010

Wrch-1 is an atypical Rho family small GTPase with roles in migration, epithelial cell morphogenesis, osteoclastogenesis, and oncogenic transformation. Here, we observed rapid relocalization of… (More)

Using inhibitors of prenylation to block localization and transforming activity.

• Anastacia C. Berzat, Donita C Brady, James J. Fiordalisi, Adrienne D Cox
• Methods in enzymology
• 2006

The proper subcellular localization and biological activity of most Ras and Rho family small GTPases are dependent on their posttranslational modification by isoprenylation. Farnesyltransferase… (More)

Visual monitoring of post-translational lipid modifications using EGFP-GTPase probes in live cells.

• Patricia J. Keller, James J. Fiordalisi, Anastacia C. Berzat, Adrienne D Cox
• Methods
• 2005

Modification of small GTPases by lipids is required for their proper subcellular localization and biological activity. Lipids added post-translationally include both farnesyl and geranylgeranyl… (More)

Farnesylated proteins: how do they get to where they need to go, and how does location regulate their ability to control proliferation, death, transformation and aging?

• Adrienne D Cox, James P. Madigan, +11 authors Francis S. Collins
• 2006

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