- Full text PDF available (3)
- This year (0)
- Last 5 years (0)
- Last 10 years (15)
Journals and Conferences
Direct activation of sp C H bonds a to a nitrogen atom represents an attractive strategy for functionalization of amines, especially those found in 5and 6-membered ring heterocycles. In particular, C… (More)
A short and efficient synthesis of the important drug candidate telaprevir (IX), featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps is presented.
Time and pep-tide wait for no man: Optically pure 3,4disubstituted 1-pyrrolines, generated from the corresponding meso-pyrrolidines by biocatalytic desymmetrization (MAO-N=monoamine oxidase N), react… (More)
3,4-cis-substituted imines, such as (I), prepared via biocatalytic desymmetrization as reported earlier, are used as imine components in an Ugi-type multicomponent reaction.
Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords… (More)
An efficient combination of MAO-N-catalyzed desymmetrization of cyclic meso-amines with Ugi-Smiles multicomponent chemistry produced optically pure N-aryl proline amides. This method represents the… (More)
A very short and efficient synthesis of the important drug candidate telaprevir, featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps, is presented. The… (More)
We have combined the biocatalytic desymmetrization of 3,4-cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet-Spengler-type cyclization reaction… (More)