Anand Sivaramakrishnan

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BACKGROUND Drug-resistant tuberculosis (TB), especially multidrug-resistant (MDR, resistance to rifampicin and isoniazid) disease, is associated with a worse patient outcome. Drug resistance diagnosed using microbiological culture takes days to weeks, as TB bacteria grow slowly. Rapid molecular tests for drug resistance detection (1 day) are commercially(More)
We obtained spectra, in the wavelength range λ = 995−1769 nm, of all four known planets orbiting the star HR 8799. Using the suite of instrumentation known as Project 1640 on the Palomar 5-m Hale Telescope, we acquired data at two epochs. This allowed for multiple imaging detections of the companions and multiple extractions of low-resolution (R ∼ 35)(More)
BACKGROUND A noninvasive technique for testing endothelial function by ultrasound measurement of flow-mediated dilatation has recently generated considerable interest as a marker of atherosclerosis, and in the prediction of clinical coronary events and coronary artery disease. METHODS AND RESULTS We measured the flow-mediated dilatation of the brachial(More)
We present an analysis of the orbital motion of the four sub-stellar objects orbiting HR8799. Our study relies on the published astrometric history of this system augmented with an epoch obtained with the Project 1640 coronagraph + Integral Field Spectrograph (IFS) installed at the Palomar Hale telescope. We first focus on the intricacies associated with(More)
We report a case of Toscana virus encephalitis. This emerging pathogen is among the three most common causes of meningoencephalitis in Europe during the warm season, yet remains under-recognised. Doctors should consider Toscana virus infection in patients presenting with neurological symptoms who have a relevant exposure history during the summer months.
We describe the symmetries present in the point-spread function (PSF) of an optical system either located in space or corrected by an adaptive optics (AO) system to Strehl ratios of about 70% and higher. We present a formalism for expanding the PSF to arbitrary order in terms of powers of the Fourier transform of the residual phase error, over an(More)
Streptococcus pneumoniae is the leading bacterial opportunistic infection (OI) in HIV positive individuals. Anti-retroviral treatment (ART) reduces their risk of Invasive Pneumococcal Disease (IPD), however, it remains 20- to 40-fold greater than that of the general population. In HIV-infected adults, pneumococcal vaccination (PCV) induces more durable and(More)
The major obstacle to the direct detection of companions to nearby stars is the overwhelming brightness of the host star. Current instruments employing the combination of adaptive optics (AO) and coronagraphy can typically detect objects within 2 of the star that are ∼ 10 times fainter. Correlated speckle noise is one of the biggest obstacles limiting such(More)
We describe a new instrument that forms the core of a long-term high contrast imaging program at the 200 inch (5 m) Hale Telescope at Palomar Observatory. The primary scientific thrust is to obtain images and lowresolution spectroscopy of brown dwarfs and young exoplanets of several Jupiter masses in the vicinity of stars within 50 pc of the Sun. The(More)