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A novel power on reset (POR) circuit with brown out (BO) detector having zero steady state current consumption is proposed. The circuit has been designed in 65nm CMOS process at a single supply of 1.1V. Both the POR and BO thresholds are independently adjustable in the circuit. Simulation results show that the POR threshold does not depend upon the supply(More)
2D quantitative structure–activity relationships (2D QSAR) and hologram quantitative structure–activity relationship (HQSAR) studies were performed on a series of polysubstituted quinoline derivatives as inhibitors of phosphodiesterase 4 (PDE4). The dataset was divided into training set and test set by K-means clustering. 2D QSAR study was carried out using(More)
3D QSAR models using 3D pharmacophore, CoMFA, and CoMSIA approaches were developed for a series of quinoline derivatives as PDE4 receptor antagonists. Hypogen method was used to engender the 3D pharmacophore model. The top scoring four feature pharmacophore models, Hypo1 contains one hydrogen-bond acceptor, two hydrogen-bond donors, and a hydrophobic(More)
Human African Trypanosomiasis is endemic to 37 countries of sub-Saharan Africa. It is caused by two related species of Trypanosoma brucei. Current therapies suffer from resistance and public accessibility of expensive medicines. Finding safer and effective therapies of natural origin is being extensively explored worldwide. Pentamidine is the only available(More)
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