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1,5-Benzothiazepine, a versatile pharmacophore: a review.
3,5-dibenzoyl-1,4-dihydropyridines: synthesis and MDR reversal in tumor cells.
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.
Recent advances in proton pump inhibitors and management of acid-peptic disorders.
Synthesis, in vitro antitubercular activity and 3D-QSAR study of 1,4-dihydropyridines
The synthesis of 97 various symmetrical, unsymmetrical, and N-substituted 1,4-dihydropyridines revealed the importance of the conformational flexibility of the substituents in antitubercular activity.
Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard-quinoline conjugates having a urea or hydrazinecarboxamide linker.
Novel antitumor indolizino[6,7-b]indoles with multiple modes of action: DNA cross-linking and topoisomerase I and II inhibition.
Results revealed that compound 18a was more potent than irinotecan against HT-29 cells and was as potent as ir inotecans against A549 cells in xenograft models.
Synthesis, anti-tubercular activity and 3D-QSAR study of coumarin-4-acetic acid benzylidene hydrazides.
Screening for In Vitro Antimycobacterial Activity and Three‐Dimensional Quantitative Structure–Activity Relationship (3D‐QSAR) Study of 4‐(arylamino)coumarin Derivatives
- Vijay Virsdoia, M. Shaikh, E. Coutinho
- Biology, ChemistryChemical biology & drug design
- 1 November 2010
A small library of 50 analogues of 4‐(arylamino)coumarins with various aromatic amines at the C4‐ position of the coumarin scaffold is synthesized, finding compound 9 was found to be most potent with a minimum inhibitory concentration >6.25 μg/mL for 100% inhibition.
3,5‐Dibenzoyl‐4‐(3‐phenoxyphenyl)‐1,4‐dihydro‐2,6‐dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility
DP7 may represent a lead compound for the development of potent dihydropyridine MDR chemosensitizers devoid of vascular effects.