• Publications
  • Influence
1,5-Benzothiazepine, a versatile pharmacophore: a review.
3,5-dibenzoyl-1,4-dihydropyridines: synthesis and MDR reversal in tumor cells.
Synthesis, in vitro antitubercular activity and 3D-QSAR study of 1,4-dihydropyridines
TLDR
The synthesis of 97 various symmetrical, unsymmetrical, and N-substituted 1,4-dihydropyridines revealed the importance of the conformational flexibility of the substituents in antitubercular activity.
Novel antitumor indolizino[6,7-b]indoles with multiple modes of action: DNA cross-linking and topoisomerase I and II inhibition.
TLDR
Results revealed that compound 18a was more potent than irinotecan against HT-29 cells and was as potent as ir inotecans against A549 cells in xenograft models.
Screening for In Vitro Antimycobacterial Activity and Three‐Dimensional Quantitative Structure–Activity Relationship (3D‐QSAR) Study of 4‐(arylamino)coumarin Derivatives
TLDR
A small library of 50 analogues of 4‐(arylamino)coumarins with various aromatic amines at the C4‐ position of the coumarin scaffold is synthesized, finding compound 9 was found to be most potent with a minimum inhibitory concentration >6.25 μg/mL for 100% inhibition.
3,5‐Dibenzoyl‐4‐(3‐phenoxyphenyl)‐1,4‐dihydro‐2,6‐dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility
TLDR
DP7 may represent a lead compound for the development of potent dihydropyridine MDR chemosensitizers devoid of vascular effects.
...
...