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1,5-Benzothiazepine, a versatile pharmacophore: a review.
TLDR
Structural modifications done for various targets of 1,5-benzodiazepines along with the brief description of the targets are mainly covered. Expand
3,5-dibenzoyl-1,4-dihydropyridines: synthesis and MDR reversal in tumor cells.
TLDR
3,5-dibenzoyl-4-(3-chlorophenyl)-1,4-dihydro-2,6-dimethylpyridine can be recommended as a new drug candidate for MDR cancer treatment. Expand
Recent advances in proton pump inhibitors and management of acid-peptic disorders.
TLDR
The emphasis has been laid on the role of proton pump inhibitors widely used nowadays for the treatment of gastric acid diseases and the medicinal chemistry aspects and mechanism of action of irreversible PPIs and APAs at molecular levels. Expand
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.
TLDR
The research done on the discovery and evaluation of a variety of chemically diverse structures as selective antagonists of alpha( 1)-adr and alpha(1)-adr subtypes in recent years has been reviewed. Expand
Synthesis, in vitro antitubercular activity and 3D-QSAR study of 1,4-dihydropyridines
TLDR
The synthesis of 97 various symmetrical, unsymmetrical, and N-substituted 1,4-dihydropyridines revealed the importance of the conformational flexibility of the substituents in antitubercular activity. Expand
Synthesis and Biological Screening of Pyrano[3,2-c]quinoline Analogues as Anti-inflammatory and Anticancer Agents.
TLDR
It is suggested that 3-substitution on the aryl ring at C4 position of the pyrano[3,2-c]quinolone structural motif seems to be an important position for both TNF-α and IL-6 inhibition and anticancer activity as well. Expand
Synthesis, anti-tubercular activity and 3D-QSAR study of coumarin-4-acetic acid benzylidene hydrazides.
TLDR
A set of 25 coumarin-4-acetic acid benzylidene hydrazides synthesized and characterized by NMR, IR and mass spectroscopic techniques provided a good insight into the structure activity relationships of the compounds reported herein. Expand
Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard-quinoline conjugates having a urea or hydrazinecarboxamide linker.
TLDR
It was revealed that both linkers are able to lower the chemically reactive N-mustard pharmacophore and thus the newly synthesized conjugates possess a long half-life in rat plasma. Expand
Screening for In Vitro Antimycobacterial Activity and Three‐Dimensional Quantitative Structure–Activity Relationship (3D‐QSAR) Study of 4‐(arylamino)coumarin Derivatives
TLDR
A small library of 50 analogues of 4‐(arylamino)coumarins with various aromatic amines at the C4‐ position of the coumarin scaffold is synthesized, finding compound 9 was found to be most potent with a minimum inhibitory concentration >6.25 μg/mL for 100% inhibition. Expand
3,5‐Dibenzoyl‐4‐(3‐phenoxyphenyl)‐1,4‐dihydro‐2,6‐dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility
TLDR
DP7 may represent a lead compound for the development of potent dihydropyridine MDR chemosensitizers devoid of vascular effects. Expand
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