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BACKGROUND EGFR overexpression has been described in many human tumours including gastric cancer. In NSCLC patients somatic EGFR mutations, within the kinase domain of the protein, as well as gene amplification were associated with a good clinical response to EGFR inhibitors. In gastric tumours data concerning structural alterations of EGFR remains(More)
Germline mutations of E-cadherin gene (CDH1) occur in 30% of families with Hereditary Diffuse Gastric Cancer (HDGC); of these, 23% are missense mutations. The CDH1 missense mutations described to date span the entire gene and most of them are functionally relevant and constitute a invaluable model do study E-cadherin dependent signaling pathways and find(More)
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