Ana Peña

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Recently, we synthesized and characterized the first selective V(1b) vasopressin (VP)/oxytocin receptor agonist, d[Cha(4)]arginine vasopressin. However, this agonist was only selective for the human receptors. We thus decided to design a selective V(1b) agonist for the rodent species. We started from previous observations showing that modifying(More)
Let {Pn} n≥0 be a sequence of monic orthogonal polynomials with respect to a quasi–definite linear functional u and {Qn} n≥0 a sequence of polynomials defined by Qn(x) = Pn(x) + sn Pn−1(x) + tn Pn−2(x), n ≥ 1, with tn = 0 for n ≥ 2. We obtain a new characterization of the orthogonality of the sequence {Qn} n≥0 with respect to a linear functional v, in terms(More)
Angiotensin II (Ang-II) regulates a variety of cellular functions including cortisol secretion. In the present report, we demonstrate that Ang-II activates phospholipase D (PLD) in zona fasciculata (ZF) cells of bovine adrenal glands, and that this effect is associated to the stimulation of cortisol secretion by this hormone. PLD activation was dependent(More)
Starting from the 2.8-A resolution x-ray structure of bovine rhodopsin, three-dimensional molecular models of the complexes between arginine vasopressin and two receptor subtypes (V1a, V1b) have been built. Amino acid sequence alignment and docking studies suggest that four key residues (1.35, 2.65, 4.61, and 5.35) fine tune the binding of vasopressin and(More)
We consider a generalization of the classical Hermite polynomials by the addition of terms involving derivatives in the inner product. This type of generalization has been studied in the literature from the point of view of the algebraic properties. Thus, our aim is to study the asymptotics of this sequence of nonstandard orthogonal polynomials. In fact, we(More)
This paper deals with Mehler–Heine type asymptotic formulas for the so-called discrete Sobolev orthogonal polynomials whose continuous part is given by Laguerre and generalized Hermite measures. We use a new approach which allows to solve the problem when the discrete part contains an arbitrary (finite) number of mass points.
Let { ℙ n } n ≥ 0 $\{\mathbb{P}_{n}\}_{n\ge 0}$ and { ℚ n } n ≥ 0 $\{\mathbb{Q}_{n}\}_{n\ge 0}$ be two monic polynomial systems in several variables satisfying the linear structure relation ℚ n = ℙ n + M n ℙ n − 1 , n ≤ 1 , $\mathbb{Q}_{n} = \mathbb{P}_{n} + M_{n} \mathbb{P}_{n-1}, \quad n\ge 1,$ where M n are constant matrices of proper size and ℚ 0 = ℙ 0(More)
In this article we present a methodology for the generation of optimal layouts in milk goats' units, characteristic of the south of Spain. For this purpose we used the S.L.P. (Systematic Layout Planning) methodology developed for the planning of industrial facilities, and a computer program for layout generation based on genetic algorithms and on " slicing(More)