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We have bred a Pkd1 floxed allele with a nestin-Cre expressing line to generate cystic mice with preserved glomerular filtration rate to address the pathogenesis of complex autosomal dominant… (More)
Mutations in PKD1 cause the majority of cases of autosomal dominant polycystic kidney disease (ADPKD). Because polycystin 1 modulates cell proliferation, cell differentiation, and apoptosis, its… (More)
A maior parte dos casos de doenca renal policistica autossomica dominante (DRPAD) e causada por mutacoes no gene PKD1 (Polycystic Kidney Disease 1). O insulto por isquemia/reperfusao (IR)… (More)
BACKGROUND Subsequent ischaemic episodes may induce renal resistance. P21 is a cell cycle inhibitor that may be induced by oxygen-free radicals and may have a protective effect in ischaemic acute… (More)
The Newcastle’s disease is a contagious viral pathology that infects both domestic and wild birds, having, thus, a high epidemic risc and it can impact negatively the economy. Nowadays, the available… (More)
OBJECTIVE End-stage renal disease is a health problem that consumes public and private resources. This study aimed to identify the cost of hemodialysis (either daily or conventional hemodialysis) and… (More)