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  • Jan Beněs, A Fabián Parada, +6 authors Patrício Soares-da-Silva
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1999 (First Publication: 1 July 1999)
  • A series of esters of the major metabolite of oxcarbazepine (2), 10, 11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, were synthesized and evaluated for their anticonvulsant and brainContinue Reading
  • David Alexander Learmonth, Maria Augusta Vieira-Coelho, +4 authors Patrício Soares da-Silva
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2002
  • A homologous series of novel nitro-catechol structures (7a-7e) were synthesized and tested as inhibitors of the enzyme catechol-O-methyltransferase (COMT). Increasing chain length was found to haveContinue Reading
    Abstract The complexes [Eu(eta) 2 ·(H 2 O) 4 ]Cl and [Eu(eta) 2 ·(phen)·(H 2 O) 2 ]Cl (eta = Etil 4,4,4-trifluoroacetoacetate; phen = 1,10-phenanthroline) are synthesized and characterized. TheContinue Reading
  • Brian L. Booth, Robin G. Pritchard, Ana P Freitas, M. F. J. R. P. Proenca
  • Chemistry
  • 1993 (First Publication: 15 September 1993)
  • In the triazepine, a double bond links atoms 1 and 2 [C=N = 1.276 (3) A] with no evidence of an alternative tautomer in which the double bond is between 2 and 3 [C-C = 1.490 (4) A]. 1 H NMRContinue Reading
    Acetylcholinesterase (AChE) is an important enzyme in the control of the neuronal action potential and sensitive to organophosphate inhibition. Brain fish AChE is less sensitive to organophosphateContinue Reading