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Minocycline, an antibiotic of the tetracycline family, has attracted considerable interest for its theoretical therapeutic applications in neurodegenerative diseases. However, the mechanism of action underlying its effect remains elusive. Here we have studied the effect of minocycline under excitotoxic conditions. Fluorescence and bioluminescence imaging(More)
Brain senescence and neurodegeneration occur with a mitochondrial dysfunction characterized by impaired electron transfer and by oxidative damage. Brain mitochondria of old animals show decreased rates of electron transfer in complexes I and IV, decreased membrane potential, increased content of the oxidation products of phospholipids and proteins and(More)
Presence of intracytoplasmatic apolipoprotein D (apo D), a lipophilic ligand transporter, was investigated in normal human brains between 20 and 55 years, using an anti-human apolipoprotein D antibody and extravidin-biotin-enhanced immunohistochemistry. Apo D immunoreactivity was found in neuroglial cells of white matter in all sampled brain regions studied(More)
Male mice receiving vitamin E (5.0 g alpha-tocopherol acetate/kg of food) from 28 wk of age showed a 40% increased median life span, from 61 +/- 4 wk to 85 +/- 4 wk, and 17% increased maximal life span, whereas female mice equally supplemented exhibited only 14% increased median life span. The alpha-tocopherol content of brain and liver was 2.5-times and(More)
A quantitative study regarding the age-related changes occurring in the nucleus and the somatic organelles of neurosecretory magnocellular neurons of the hypothalamo neurohypophyseal system (HNS) was carried out in the hamster at six age-points during animal life. The magnocellular cells of both parts of the supraoptic nucleus (SON) and the paraventricular(More)
The parvocellular neurons of the parvocellular division of the paraventricular nucleus (PVPA) were studied in hamsters at six point ages (from 3 to 30 months old). Standard manual morphometric techniques were used to obtain data of parvocellular activity including nuclear and nucleolar size, as well as the percentage of the cell occupied by Golgi apparatus(More)
Two women suffered from strictly unilateral, periocular headaches for many years. The clinical characteristics of headaches were those described in chronic paroxysmal hemicrania. However, both patients showed an episodic evolution of pain. In one case, this stage could be considered pre-chronic because it was later followed by the classic and apparently(More)
The characteristics of the four major vestibular nuclei and accessory cell groups in the rat have been studied in serially cut horizontal sections. Camera lucida drawings of the vestibular nuclei and their neurons were made in these sections and subjected to a computerized image analysis. The dimensions (volume and length) and the number of cells of each(More)
The present paper describes the presence of a special cell located in the ependymal wall at the level of the paraventricular nucleus. At this level, ultrastructural observation of these ependymal cells, unlike most other mammalian species, shows the presence of nucleolus-like bodies in their cytoplasm and occasionally basal processes. These processes appear(More)
BACKGROUND Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group. METHODS Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in(More)