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During mitosis, bundles of microtubules form a spindle, but the physical mechanism of bundle formation is still not known. Here we show that random angular movement of microtubules around the spindle pole and forces exerted by passive cross-linking proteins are sufficient for the formation of stable microtubule bundles. We test these predictions by(More)
During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed between sister kinetochores, but their function is unknown. Here we show by laser-cutting of a k-fibre in HeLa and PtK1 cells that a bundle of non-kinetochore microtubules,(More)
During cell division, mitotic spindle microtubules segregate chromosomes by exerting forces on kinetochores. What forces drive chromosome segregation in anaphase remains a central question. The current model for anaphase in human cells includes shortening of kinetochore fibers and separation of spindle poles. Both processes require kinetochores to be linked(More)
with Silicon SF 96 fluid on firebrick using helium as the effluent gas (60 ml. per minute); only a single peak was observed in each case. Cuprous Bromide-catalyzed Reactions of l-Butyl Perbenzoate and Cyclohexene in Aliphatic Acids.-The reactions were again carried out under similar conditions. Over a period of oiie hour, t-butyl perbenzoate (0.2 mole) K:LS(More)
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