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- Angelo Oscar Rosa, Jaime Lin, João Batista Calixto, Adair Roberto Soares dos Santos, Ana Lúcia S Rodrigues
- Behavioural brain research
- 2003
This study investigated the involvement of NMDA receptors and the L-arginine-nitric oxide (NO) pathway in the antidepressant-like effects of zinc in the forced swimming test (FST). The immobility… (More)
Pro-inflammatory cytokines are implicated in the pathogenesis of depression. However, few animal models of cytokine-induced depression well characterized regarding its response to antidepressants are… (More)
- John E. Piletz, Feyza Aricioğlu, +15 authors Gad M Gilad
- Drug discovery today
- 2013
Agmatine (decarboxylated arginine) has been known as a natural product for over 100 years, but its biosynthesis in humans was left unexplored owing to long-standing controversy. Only recently has the… (More)
Agmatine produces an antidepressant-like effect when assessed in the forced swimming test (FST) and in the tail suspension test (TST) in mice (dose range 0.01-50 mg/kg, i.p.), without accompanying… (More)
- Michela Mantovani, Roberto Pértile, João Batista Calixto, Adair Roberto Soares dos Santos, Ana Lúcia S Rodrigues
- Neuroscience letters
- 2003
This study investigated the effect of melatonin in the mouse tail suspension test (TST), and the contribution of N-methyl-D-aspartate (NMDA) receptors and the L-arginine-nitric oxide (NO) pathway to… (More)
- Ricardo Wabner Binfaré, Angelo Oscar Rosa, Kelly Ribas Lobato, Adair Roberto Soares dos Santos, Ana Lúcia S Rodrigues
- Progress in Neuro-Psychopharmacology and…
- 2009
Ascorbic acid is highly concentrated in the brain, being considered as a neuromodulator. This study investigated the effect of ascorbic acid in the tail suspension test (TST) and in the forced… (More)
- Mauricio P Cunha, Daniele Machado, Luis E B Bettio, Juliano C. Capra, Ana Lúcia S Rodrigues
- Progress in neuro-psychopharmacology & biological…
- 2008
The antidepressant-like effect of zinc has been shown in several animal models of depression. In this study, zinc chloride (ZnCl2) was given alone or in combination with different classes of… (More)
- Patricia S Brocardo, Josiane Budni, Manuella Pinto Kaster, Adair Roberto Soares dos Santos, Ana Lúcia S Rodrigues
- Neuropharmacology
- 2008
Clinical studies have shown that folic acid plays a role in the pathophysiology of depression. However, very few studies have investigated its effect in behavioral models of depression. Hence, this… (More)
- Alan L Eckeli, Fabíola É. Dach, Ana Lúcia S Rodrigues
- Neuroreport
- 2000
This study examined the effect of GMP in two models of depression in mice. The immobility times in the forced swimming test (FST) and in the tail suspension test (TST) were significantly reduced by… (More)
- Rúbia C Almeida, Cristiane S Felisbino, Manuela García López, Ana Lúcia S Rodrigues, Nelson Horácio Gabilan
- Behavioural brain research
- 2006
This study investigated the involvement of the L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway in the antidepressant-like effect of an acute administration of memantine in… (More)