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- Angelo Oscar Rosa, Jaime Lin, João Batista Calixto, Adair Roberto Soares dos Santos, Ana Lúcia S Rodrigues
- Behavioural brain research
- 2003
This study investigated the involvement of NMDA receptors and the L-arginine-nitric oxide (NO) pathway in the antidepressant-like effects of zinc in the forced swimming test (FST). The immobility… (More)
Agmatine produces an antidepressant-like effect when assessed in the forced swimming test (FST) and in the tail suspension test (TST) in mice (dose range 0.01-50 mg/kg, i.p.), without accompanying… (More)
Pro-inflammatory cytokines are implicated in the pathogenesis of depression. However, few animal models of cytokine-induced depression well characterized regarding its response to antidepressants are… (More)
- Ricardo Wabner Binfaré, Angelo Oscar Rosa, Kelly Ribas Lobato, Adair Roberto Soares dos Santos, Ana Lúcia S Rodrigues
- Progress in neuro-psychopharmacology & biological…
- 2009
Ascorbic acid is highly concentrated in the brain, being considered as a neuromodulator. This study investigated the effect of ascorbic acid in the tail suspension test (TST) and in the forced… (More)
- Michela Mantovani, Roberto Pértile, João Batista Calixto, Adair Roberto Soares dos Santos, Ana Lúcia S Rodrigues
- Neuroscience letters
- 2003
This study investigated the effect of melatonin in the mouse tail suspension test (TST), and the contribution of N-methyl-D-aspartate (NMDA) receptors and the L-arginine-nitric oxide (NO) pathway to… (More)
- Mauricio P Cunha, Daniele Machado, Luis E B Bettio, Juliano C. Capra, Ana Lúcia S Rodrigues
- Progress in neuro-psychopharmacology & biological…
- 2008
The antidepressant-like effect of zinc has been shown in several animal models of depression. In this study, zinc chloride (ZnCl2) was given alone or in combination with different classes of… (More)
- Daniele Machado, Luis E B Bettio, +4 authors Ana Lúcia S Rodrigues
- Progress in neuro-psychopharmacology & biological…
- 2009
Rosemary, Rosmarinus officinalis L. (Labiatae) has several therapeutic applications in folk medicine in curing or managing a wide range of diseases, including depression. In this study, the effect of… (More)
- John E. Piletz, Feyza Aricioğlu, +15 authors Gad M Gilad
- Drug discovery today
- 2013
Agmatine (decarboxylated arginine) has been known as a natural product for over 100 years, but its biosynthesis in humans was left unexplored owing to long-standing controversy. Only recently has the… (More)
L-Arginine (L-Arg), a substrate for nitric oxide synthase (NOS) at a dose of 250-500 mg/kg, i.p., significantly reduced the duration of immobility both in the forced swimming test (FST) and in the… (More)
- Patricia S Brocardo, Josiane Budni, Manuella Pinto Kaster, Adair Roberto Soares dos Santos, Ana Lúcia S Rodrigues
- Neuropharmacology
- 2008
Clinical studies have shown that folic acid plays a role in the pathophysiology of depression. However, very few studies have investigated its effect in behavioral models of depression. Hence, this… (More)