Ana Lúcia Borges Starling

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This study compared the proviral load and the plasma cytokine profiles (interleukin-IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ) in 87 HTLV-1-infected individuals, including 28 with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), 32 with possible pHAM/TSP and 27 asymptomatic carriers (AC). The control group was composed by 21(More)
HTLV-1 Associated Myelopathy/Tropical spastic paraparesis (HAM/TSP) is the classical neurological syndrome associated with this retrovirus, although other neurological complications are described. We collected data in the neurological and epidemiological databases related of the GIPH cohort, from 1997 and 2012, as well as in the records of the participants.(More)
This study aimed at establishing the immunological signature and an algorithm for clinical management of the different clinical stages of the HTLV-1-infection based on serum biomarkers. A panel of serum biomarkers was evaluated by four sets of innovative/non-conventional data analysis approaches in samples from 87 HTLV-1 patients: asymptomatic carriers(More)
Introduction Galvanic vestibular stimulation (GVS) is a low-cost and safe exam that tests the vestibulospinal pathway. HTLV1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a slowly progressive disease that precociously affects the vestibulospinal tract. This study compared electromyographic (EMG) responses triggered by GVS between(More)
Dizziness is a common complaint in HAM/TSP and can occur due to vestibulospinal tract dysfunction. This tract can be assessed through Vestibular Evoked Myogenic Potential (VEMP). The aim was to correlate the result of VEMP generated by acoustic stimuli and dizziness in individuals with HTLV-1-asymptomatic infection and HAM/TSP. VEMP was recorded from(More)
The present work provides an innovative methodological approach to assess the anti-HTLV-1 IgG1 reactivity with practical application in clinical laboratory. Serum from non-infected healthy controls (NI) and HTLV-1-infected patients, categorized as asymptomatic (AS), putatively progressing to HTLV-1 associated myelopathy/tropical spastic paraparesis -(More)
Dizziness is a symptom in human T cell lymphotropic virus type-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and may occur due to vestibulospinal tract dysfunction. This tract can be assessed by an electrophysiological test called vestibular-evoked myogenic potential (VEMP). The aim was to correlate the result of VEMP generated by acoustic(More)
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