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Lung cancer is the most lethal form of cancer in the world and despite significant therapeutic improvements that have been made, its survival rate still remains low. The latter is mainly due to the acquisition of resistance to systemic treatment regimens which, in turn, may be due to the presence of cancer stem cells (CSCs) within the primary tumors. CSCs(More)
Glioblastoma multiforme is the most lethal of brain cancer, and it comprises a heterogeneous mixture of functionally distinct cancer cells that affect tumor progression. We examined the U87, U251, and U373 malignant cell lines as in vitro models to determine the impact of cellular cross-talk on their phenotypic alterations in co-cultures. These cells were(More)
Epithelial-mesenchymal transition (EMT) is the underlying mechanism of tumor invasion and metastasis. Evidences from lung cancer cellular models show EMT can trigger conversion to a cancer stem cell (CSC) phenotype. In this study, we assessed mRNA expression levels of EMT-inducing transcription factors (BMI1, TWIST1), CSC (CD133, ALDH1A1), and epithelial(More)
The rarity of circulating tumour cells (CTCs) in peripheral blood requires the application of sensitive techniques for their detection. The aim of our study was to (i) first determine the sensitivity of cytokeratin-7 (KRT7) mRNA expression levels for the molecular detection of CTCs using spiked-in lung adenocarcinoma (AC)-derived A549 cells and (ii)(More)
Ambient Assisted Living environments rely heavily on use of technology for providing its users with assistance or supervision in their Activities of Daily Living (ADLs). Thus, it is crucial to ensure that wireless sensor networks (WSN) have high reliability and availability in such systems. Performance of networks is measured by the packet delivery ratio,(More)
Constant struggle in medical science to develop new, more advanced methods of medicine application and reducing the invasiveness of a range of tests and procedures is present. For achieving this ambitious goal, it is necessary to find and develop new methods and technologies and to applicate them. The issue of localizing a range of devices inside the human(More)
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