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Although it has been demonstrated that NO inhibits the proliferation of different cell types, the mechanisms of its anti-mitotic action are not well understood. In this work we have studied the possible interaction of NO with the epidermal growth factor receptor (EGFR), using transfected fibroblasts which overexpress the human EGFR. The NO donors(More)
Renal blood flow autoregulation was studied in deoxycorticosterone acetate (DOCA)-treated rats. DOCA pellets (75 mg) were implanted in uninephrectomized rats, and the animals were then fed one of four diets: (1) normal sodium chloride level, (2) high in NaCl, (3) high in chloride, or (4) high in sodium. After 40 to 45 days of the DOCA-diet treatment,(More)
The temporal pattern of hypothalamic and limbic aminergic activity during the estrous cycle has been measured by changes in the serotonergic and noradrenergic neuronal uptake during the regular estrous cycle. Significant changes (p = 0.006, 0.01) in the uptake of 3H 5-HT and 3H NE were recorded in the suprachiasmatic nuclei (SCN) at 1200 hours on proestrus.(More)
Changes in tyrosine hydroxylase (TH) activity in the whole hypothalamus and discrete nuclear regions of the limbic system were observed to occur from 10 to 40 days of age in the female rat. In the whole hypothalamus, TH activity increased between 10 and 30 days of age then decreased at 40 days of age. In the preoptic (POA) and suprachiasmatic nuclear areas(More)
INTRODUCTION [corrected] There is no "gold standard" for identification of malnutrition. The ASPEN board of directors (2002) suggest the subjective global assessment (SGA) and ESPEN (2002) recommend the nutritional risk screening-2002 (NRS-2002) to detect the prevalence of malnutrition. AIMS This cross-sectional study aims (1) to assess the prevalence of(More)
Serotonin-N-acetyltransferase (EC 2.3.1.5), partially purified from Drosophila melanogaster (DNAT) was substituted for rat liver enzyme (RNAT) in a previously published radioenzymatic assay for serotonin (5HT). The purpose was to determine if this modification would increase the sensitivity and reliability of the original assay. Compared with RNAT, DNAT is(More)
Tissue effector cells of the monocyte lineage can differentiate into different cell types with specific cell function depending on their environment. The phenotype, developmental requirements, and functional mechanisms of immune protective macrophages that mediate the induction of transplantation tolerance remain elusive. Here, we demonstrate that(More)
It has been reported that both sodium and chloride ions must be ingested to induce the elevated blood pressure of deoxycorticosterone acetate (DOCA)-salt-sensitive hypertension. This study was designed to determine the separate roles of the sodium and chloride ions in the altered hemodynamics underlying the high blood pressure. DOCA pellets (75 mg) were(More)
Recent characterization of luteinizing hormone++ (LH)/human chorionic gonadotropin (hCG) receptors in uterine vascular tissue, evidence that expression of these receptors is cyclic in nature, and demonstration of a correlation between hCG level and uterine vascular resistance lead us to investigate the effect of hCG administration on blood flow in(More)