Cell cycle arrest through inhibition of tubulin polymerization by withaphysalin F, a bioactive compound isolated from Acnistus arborescens
Results suggest that interference of withaphysalin F in microtubule polymerization may induce cell cycle arrest in the G2/M phase and therefore contribute to growth inhibition of tumor cells in vitro.
Further Withaphysalin Derivatives from Acnistus arborescens
- Ana Isabel V. Maia, R. Braz-Filho, E. Silveira, C. A. Simone, O. Pessoa
- Chemistry
- 1 August 2012
Two new epimeric chlorinated withaphysalins, rel-(4β,5β,6α,18S,22R)- and rel-(4β,5β,6α,18R,22R)-6-chloro-18,20-epoxy-18-ethoxy-4,5-dihydroxy-1-oxowitha-2,24-diene-26,22-lactone (1 and 2 resp.),…
Cytotoxic cordiaquinones from the roots of Cordia polycephala
- H. P. S. Freitas, Ana Isabel V. Maia, O. Pessoa
- Chemistry
- 1 August 2012
The chemical investigation of roots of Cordia polycephala resulted in the isolation of two new terpenoid naphtoquinones,…
Palyosulfonoceramides A and B: Unique Sulfonylated Ceramides from the Brazilian Zoanthids Palythoa caribaeorum and Protopalyhtoa variabilis
- J. G. L. Almeida, Ana Isabel V. Maia, O. Pessoa
- ChemistryMarine Drugs
- 1 December 2012
Two unprecedented sulfonylated ceramides are reported from specimens collected off Brazil’s northeastern coast using a combination of NMR analyses, high-resolution mass spectrometry and chemical degradation.