Ana Isabel Sánchez-Fructuoso

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Background. Monitoring changes in glomerular filtration rate (GFR) is the recommended method for assessing the progression of kidney disease. The aim of this study was to assess the decline of graft function defined by the annual-ized change in GFR and the factors which affect it. Methods. Four thousand four hundred and eighty-eight patients, transplanted(More)
Key words: antiglomerular basement membrane anti-previously. One year before admission, a routine body-mediated nephritis; diabetes mellitus; glom-analysis had shown serum creatinine 1.6 mg/dl erulonephritis (141.4 mmol/l). On admission, the patient's blood pressure was 160/70 mmHg, heart rate 84/min, and temperature 36.8°C; there was moderate diabetic(More)
INTRODUCTION Renal allograft half-life time (t½) is the most straightforward representation of long-term graft survival. Since some statistical models overestimate this parameter, we compare different approaches to evaluate t½. PATIENTS AND METHODS Patients with a 1-year functioning graft transplanted in Spain during 1990, 1994, 1998 and 2002 were(More)
BACKGROUND Several groups have demonstrated that non-heart beating donation is a viable source of organs for transplantation. However, the theoretically worse graft function and survival of the kidneys obtained from non-heart beating donors (NHBDs) is still a matter of debate that has led to consider them as marginal donors for kidney transplantation. (More)
It is well know that anti-HLA antibodies are an important obstacle in kidney transplantation. Our aim was to study the clinical impact of pretransplant donor specific anti-HLA antibodies (HLA-DSA), in highly sensitized (HS) patients. We analyzed retrospectively the day-of-transplant sera by Luminex Single Antigen Assay (LSA) in HS patients, and the results(More)
The -308G/A SNP of tumor necrosis factor-alpha (TNF-α) gene affects TNF-α production. As its impact on transplant outcome remains open to debate, we decided to genotype it in a cohort of transplant subjects. A retrospective analysis of 439 first kidney recipients randomly divided into two subgroups (discovery and validation cohorts) was performed to(More)
UNLABELLED Calcineurin inhibitor-associated nephrotoxicity and other adverse events have prompted efforts to minimize/eliminate calcineurin inhibitor use in kidney transplant recipients. METHODS This open-label, randomized, multinational study evaluated the effect of planned transition from tacrolimus to sirolimus on kidney function in renal allograft(More)
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