Ana Ferreira

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A wide variety of tumours show PIK3CA mutations leading to increased phosphatidylinositol-3 kinase (PI3K) activity. We have determined the frequency of PIK3CA mutations in exons 9 and 20 that has previously been reported as mutational hotspot regions in distinct tumour models. One hundred and fifty gastrointestinal carcinomas (47 gastric and 103 colorectal)(More)
In sporadic colorectal tumours the BRAFV600E is associated with microsatellite instability (MSI-H) and inversely associated to KRAS mutations. Tumours from hereditary non-polyposis colorectal cancer (HNPCC) patients carrying germline mutations in hMSH2 or hMLH1 do not show BRAFV600E, however no consistent data exist regarding KRAS mutation frequency and(More)
The Electronic Medical Record (EMR) is a very important support tool for patients and healthcare professionals but it has some barriers that prevent its successful integration within the healthcare practice. These barriers comprise not only security concerns but also costs, in terms of time and effort, as well as relational and educational issues that can(More)
Defects in the mismatch repair system lead to microsatellite instability (MSI), a feature observed in ∼ 15% of all colorectal cancers (CRCs). Microsatellite mutations that drive tumourigenesis, typically inactivation of tumour suppressors, are selected for and are frequently detected in MSI cancers. Here, we evaluated somatic mutations in microsatellite(More)
The wider use of healthcare information systems and the easier integration and sharing of patient clinical information can facilitate a wider access to medical records. The main goal of this paper is to perform a systematic review to analyze published work that studied the impact of facilitating patients' access to their medical record. Moreover, this(More)
Research on marketing and deception has identified principles of persuasion that influence human decisions. However, this research is scattered: it focuses on specific contexts and produces different taxonomies. In regard to frauds and scams, three taxonomies are often referred in the literature: Cialdini’s principles of influence, Gragg’s psychological(More)
Translating legislation and regulations into access control systems in healthcare is, in practice, not a straightforward task. Excessive regulation can create barriers to appropriate patient treatment. The main objective of this paper is to present a new methodology that can define, from legislation to practice, an access control policy as well as a RBAC(More)