Ana Fermoso García

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The proteins AP65, AP51, AP33 and AP23 synthesized by Trichomonas vaginalis organisms in high iron play a role in adherence. Multigene families encode enzymes of the hydrogenosome organelles, which have identity to adhesins. This fact raises questions regarding the compartmentalization of the proteins outside the organelle and about the interactions of(More)
Recently, we found that inhibition of putrescine synthesis by ornithine decarboxylase (ODC) significantly increased Trichomonas vaginalis adherence mediated by protein adhesins. Surprisingly and unexpectedly, trichomonal contact-dependent cytotoxicity was absent. Therefore, a role for polyamine depletion on regulation of T. vaginalis cytotoxicity mediated(More)
Trichomonas vaginalis secretes putrescine that is readily detected in vaginal secretions. We wanted to examine the effect of decreased putrescine synthesis by inhibition of ornithine decarboxylase (ODC) on T. vaginalis. One reason is because inhibition of Tritrichomonas foetus ODC results in growth arrest, destruction of hydrogenosomes, and decreased(More)
AP65 is a prominent adhesin of Trichomonas vaginalis that mediates binding of parasites to host vaginal epithelial cells (VECs). AP65 with no secretion signal sequence, membrane targeting peptide, and anchoring motif was recently found to be secreted. We first wanted to demonstrate surface association of AP65 to the parasite followed by the identification(More)
This chapter introduces different alternatives to store and manage jointly relational and eXtensible Markup Language (XML) data sources. Nowadays, businesses are transformed in e-business and have to manage large data volumes and from heterogeneous sources. To manage large amounts of information, Database Management Systems (DBMS) continue to be one of the(More)
Nowadays, most of libraries are computerized, and moreover they have available for users their basicservices through the Web. Recent studies have concluded that 40% of people have an Internet connection, and therefore, these basic-services of libraries would be available to those people from where they are connected. If we consider that 100% of users(More)
XML has become the most useful standard of data interchange in the web and e-business world and there is a large amount of information stored in this format. Nonetheless, a large quantity of information remains stored in Relational Databases. It is very important to be able to jointly manage these two data formats. One solution would be an integrated query(More)
OMG (Object Management Group) has defined the MDA (Model Driven Architecture) specification trying to solve the actual problems of systems integration and interoperability. The main goal of this work is to introduce some basic concepts of MDA and show that is possible to define methods to transform a Platform Independent Model (PIM) to different Final Code(More)