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Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae,(More)
The sequencing of the 12 genomes of members of the genus Drosophila was taken as an opportunity to reevaluate the genetic and physical maps for 11 of the species, in part to aid in the mapping of assembled scaffolds. Here, we present an overview of the importance of cytogenetic maps to Drosophila biology and to the concepts of chromosomal evolution.(More)
Comparative genomics in Drosophila began in 1940, when Muller stated that the ancestral haploid karyotype of this genus is constituted by five acrocentric chromosomes and one dot chromosome, named A to F elements. In some species of the willistoni group such as Drosophila willistoni and D. insularis, the F element, instead of a dot chromosome, has been(More)
In this study, semi-arid environments were tested to see if they support insect diversity. This was evaluated through the structure of the composition of assemblies of drosophilids in three conservation units placed in three different ecoregions in the dryland forests, Caatinga. This is a unique biome in northeast Brazil, comprising approximately 10% of the(More)
The high-altitude wet forests of northeastern Brazil, locally known as “Brejos de Altitude,” are enclaves of the Atlantic Forest situated above 500 m, surrounded by dryland vegetation, the Caatinga. The aim of this study was to characterize drosophilid communities in these upland forests, since few ecological studies on drosophilid communities have been(More)
Mucopolysaccharidosis type I (MPSI) is a rare autosomal recessive disorder caused by mutations in the gene encoding the lysosomal enzyme α-l-iduronidase (IDUA), which is instrumental in the hydrolysis of the glycosaminoglycans, dermatan and heparan sulfate. The accumulation of unhydrolyzed glycosaminoglycans leads to pathogenesis in multiple tissue types,(More)
LETTERS and Carlos Eduardo Melo for support for viral load determination, and the blood donors who kindly consented to participate in this study.ry screening of blood donors by NAT testing for HCV-RNA: development of an " in-house " method and results. Variation of the hepatic C virus 5′ non-coding region: implications for secondary structure, virus(More)
This document summarizes the e-Gov ontology developed to support web agents to assist citizens to deal with the up growing services and information delivered in e_gov sites. We emphasized the role played by government agencies when become digital. This bias perspective will increase the effectiveness of computational agents finding their way around to(More)
Many knowledge acquisition approaches have been proposed to minimize the cognitive effort in knowledge-based system construction. The knowledge acquisition approach proposed here put together the user interaction benefits of semiformal modeling and the computational benefits of formal modeling. Our approach defines a method where the designer first(More)
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