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- Ana Coelho, Paolo Dinis, +7 authors António Avelino
- European urology
- 2010
BACKGROUND
Botulinum toxin type A (BoNTA) has been successfully used in the treatment of refractory detrusor overactivity. The toxin is internalized after binding a high-affinity receptor, synaptic… (More)
- António Manuel Araújo, Ricardo Ribeiro, +7 authors Giorgio V Scagliotti
- The oncologist
- 2007
Worldwide, approximately 1.3 billion individuals are current smokers, and smoking is the second major cause of death. Currently, lung cancer is the most common type of cancer in Europe, and the third… (More)
- Ricardo J. T. Ribeiro, Ana Paula Guimarães de Araújo, +6 authors Rui Medeiros
- European journal of cancer
- 2006
Leptin hormone and receptor have been associated to cancer development and were identified in lung tissue. In this study, a functional polymorphism in the 5' flanking region of the leptin gene (LEP… (More)
- Raquel Jorge Ferreira Catarino, Maria Manuel Ferreira, +4 authors Rui Medeiros
- DNA and cell biology
- 2008
AIM
To determine whether the amounts of circulating DNA could discriminate between breast cancer patients and healthy individuals by using real-time PCR quantification methodology.
METHODS
Our… (More)
- João Gabriel Silva, R. Âmbar Pinto, +4 authors Francisco J. Gómez-de la Cruz
- European urology
- 2009
BACKGROUND
Previous studies in humans, dogs, and rats have shown that intraprostatic injection of botulinum neurotoxin type A (BoNTA) reduces gland size.
OBJECTIVE
To investigate the role of… (More)
- Ana Coelho, Francisco J. Gómez-de la Cruz, Célia Duarte Cruz, António Avelino
- European urology
- 2012
BACKGROUND
OnabotulinumtoxinA (Onabot/A) has been used to treat detrusor overactivity disorders. The treatment is based on several injections of toxin throughout the bladder wall. However, injection… (More)
- Raquel Jorge Ferreira Catarino, Deolinda Pereira, +4 authors Rui Medeiros
- Biochemical and biophysical research…
- 2008
Cyclin D1 (CCND1) is a key regulatory protein at the G1/S checkpoint of the cell cycle. The purpose of our study was to assess the role of CCND1 genotypes influencing the age of onset of oncogenic… (More)
- Monica Moschioni, Francesco Tombola, +4 authors Cesare Montecucco
- Cellular microbiology
- 2002
Several strains of Vibrio cholerae secrete a haemolytic toxin of 63 kDa, termed V. cholerae cytolysin (VCC). This toxin causes extensive vacuolation and death of cells in culture and forms an… (More)
- Ana Coelho, Tiago Antunes-Lopes, James Gillespie, Francisco J. Gómez-de la Cruz
- Neurourology and urodynamics
- 2017
AIMS
To identify in the human bladder the structures which express the Beta-3 adrenoceptor (β3AR).
METHODS
Human bladders from cadaveric organ donors (equally balanced in sex and age) were… (More)
- Rita Cerejeira Matos, João Miguel Cordeiro, +5 authors Ana Charrua
- Acta physiologica
- 2016
AIM
Pathophysiological mechanisms of chronic visceral pain (CVP) are unknown. This study explores the association between the sympathetic system and bladder nociceptors activity by testing the effect… (More)