Ana Castro

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Although the hallmarks of neurodegeneration in Alzheimer's brains are well known, one of the current difficulties is related to the lack of solid evidence about the ultimate factors that give rise to the pathogenesis of this disease, creating a great challenge for the definition of efficient treatments for Alzheimer's disease (AD). Current therapeutic(More)
In a previous study, we demonstrated that staurosporine (STS) induces programmed cell death (PCD) in the fungus Neurospora crassa and that glutathione has the capability of inhibiting both STS-induced reactive oxygen species (ROS) formation and cell death. Here, we further investigated the role of glutathione in STS-induced PCD in N. crassa and observed an(More)
Amyloids are polymeric structural states formed from locally or totally unfolded protein chains that permit surface reorganizations, stability enhancements and interaction properties that are absent in the precursor monomers. β-Parvalbumin, the major allergen in fish allergy, forms amyloids that are recognized by IgE in the patient sera, suggesting a yet(More)
  • David Araujo-Vilar, Sofía Sánchez-Iglesias, Cristina Guillín-Amarelle, Ana Castro, Mary Lage, Marcos Pazos +7 others
  • 2015
Lipodystrophies are a group of diseases mainly characterized by a loss of adipose tissue and frequently associated with insulin resistance, hypertriglyceridemia, and hepatic steatosis. In uncommon lipodystrophies, these complications frequently are difficult to control with conventional therapeutic approaches. This retrospective study addressed the(More)
Somatosensory evoked potentials (SEPs) have been linked to noxious activation and stimulus intensity. In this exploratory study we investigated the impact of anaesthetic drugs on SEPs and pain ratings, to assess their applicability as an objective measure of the nociception/anti-nociception balance. Following institutional approval and written informed(More)
In this exploratory study we propose to analyze, in healthy adult volunteers, the heart electrical (electrocar-diogram, ECG) and mechanical (phonocardiogram, PCG) activity during exercise. Heart sounds amplitude, frequency content, and RS2, may be important features in the non-invasive assessment of heart activity, such as for the estimation of cardiac(More)
Venous air embolism (VAE) is the air bubble accumulation in the right side of the heart. Changes in Doppler heart sound (DHS) are characteristic of VAE, and the anesthesiologist has to pay attention to this event continuously, which may not always be possible. This work aims to study different features of the heart sound through a precordial Doppler, that(More)