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Primary porcine endothelial cells have a limited life span in culture. After four to five passages, they tend to de-differentiate and eventually reach senescence. The aim of this work was to establish immortalized porcine aortic endothelial cell lines (AOCs) to facilitate in vitro studies of different pathological process involving the endothelium. Primary(More)
Poly(ADP-ribose) polymerase-1 (PARP-1) has been involved in endothelial cell dysfunction associated with various pathophysiological conditions. The intrinsic mechanism of PARP-1-mediated endothelial cell dysfunction could be related to PARP-1 overactivation, NAD(+) consumption and ATP depletion. An alternative way could involve transcription regulation. By(More)
The Center for Epidemiologic Studies-Depression Scale (CES-D) is the most frequently used scale for measuring depressive symptomatology in caregiving research. The aim of this study is to test its construct structure and measurement equivalence between caregivers from two Spanish-speaking countries. Face-to-face interviews were carried out with 595 female(More)
Currently most of the design and manufacturing management systems of an enterprise deal with local and static database systems and do not consider all the involved product/process knowledge from the whole value chain. The approach presented in this paper mainly focus on those techniques that can support multidistributed clients and provide a dynamic(More)
Middlewares are used to simplify the integration of applications with different hardware and software requirements. Currently, a wide variety of middleware technologies are made available off-the-shelf to alleviate some of the complexity of developing distributed simulations. In our project, IMAGE, we have designed a middleware-based architecture to support(More)
Poly(ADP-ribose) polymerase-1 (PARP-1) plays a critical role in endothelial cell dysfunction associated with various pathophysiological conditions. To elucidate PARP-1 pathways involved in endothelial cell dysfunction, it is essential to establish "in vitro" experimental models using isolated endothelial cells. So far, two approaches have been used: primary(More)
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