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We sought to address the fundamental question of how stem cell microenvironments can regulate self-renewal. We found that Notch was active in astroglia-like neural stem cells (NSCs), but not in transit-amplifying progenitors of the murine subependymal zone, and that the level of Notch transcriptional activity correlated with self-renewal and multipotency.(More)
Knowledge of nature and features of the boundaries between the main neural regions seems to be essential to understand the rules of brain regionalization. On the light of several current and classical criteria used to define cerebral boundaries, we examine the features of the places recognized as rostral and caudal boundaries in the developing diencephalon(More)
Stem cells maintain their self-renewal and multipotency capacities through a self-organizing network of transcription factors and intracellular pathways activated by extracellular signaling from the microenvironment or "niche" in which they reside in vivo. In the adult mammalian brain new neurons continue to be generated throughout life of the organisms and(More)
The Brazilian healthcare system aims for universal access for the whole population, equity to prioritize health actions, and integrality in all assistance levels. The purpose of this research project is to promote and to evaluate intervention based on capacitation in clinical management focused on diseases that are part of the Brazilian list of ambulatory(More)
In a previous study of the embryonic midbrain radial glia in a lizard, we observed that these cells define boundaries and regional subdivisions in a pattern that largely supports the adult model [C. Diaz, C. Yanes, C.M feminine. Trujillo, L. Puelles, Cytoarchitectonic subdivisions in the subtectal midbrain of the lizard Gallotia galloti, J. Neurocytol. 29(More)
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