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The Old World arenavirus Lassa virus (LASV) is the causative agent of severe viral hemorrhagic fever (VHF) in humans and is the most prevalent human pathogen among arenaviruses. The present study investigated the largely unknown mechanisms of cell entry of LASV, a process know to be mediated solely by the virus envelope glycoprotein (GP). To circumvent(More)
Variability testing techniques search for effective and manageable test suites that lead to the rapid detection of faults in systems with high variability. Evaluating the effectiveness of these techniques in realistic settings is a must, but challenging due to the lack of variability-intensive systems with available code, automated tests and fault reports.(More)
HIV-1 infection frequently causes HIV-associated neurocognitive disorders (HAND) despite combination antiretroviral therapy (cART). Evidence is accumulating that components of cART can themselves be neurotoxic upon long-term exposure. In addition, abuse of psychostimulants, such as methamphetamine, seems to aggravate HAND and compromise antiretroviral(More)
Methamphetamine (METH) abuse is frequent in individuals infected with human immunodeficiency virus type-1 (HIV-1) and is suspected to aggravate HIV-associated neurocognitive disorders (HAND). METH is a psychostimulant that compromises several neurotransmitter systems and HIV proteins trigger neuronal injury but the combined effects of viral infection and(More)
A test oracle determines whether a test execution reveals a fault, often by comparing the observed program output to the expected output. This is not always practical, for example when a program's input-output relation is complex and difficult to capture formally. Metamorphic testing provides an alternative, where correctness is not determined by checking(More)
SUMMARY Variability determines the capability of software applications to be configured and customized. A common need during the development of variability–intensive systems is the automated analysis of their underlying variability models, e.g. detecting contradictory configuration options. The analysis operations that are performed on variability models(More)
Variability testing techniques search for effective but manageable test suites that lead to the rapid detection of faults in systems with high variability. Evaluating the effectiveness of these techniques in real settings is a must but challenging due to the lack of variability-intensive systems with available code, automated tests and fault reports. In(More)
In this paper, we report on our experience on the development of <i>La Hilandera</i>, an e-commerce site selling haberdashery products and craft supplies in Europe. The store has a huge input space where customers can place almost three millions of different orders which made testing an extremely difficult task. To address the challenge, we explored the(More)
Male breast cancer (MBC) is a rare disease that represents <1 % of all breast cancers (BCs). We analyze the results of a multicenter study performed in Spanish familial MBC including family history of hereditary breast and ovarian cancer syndrome (HBOCS) and clinicopathological features. We also study the relationship between BRCA1/BRCA2 mutational status(More)