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  • An Herreman, Dieter Hartmann, +14 authors Bart De Strooper
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1999 (First Publication: 12 October 1999)
  • Mutations in the homologous presenilin 1 (PS1) and presenilin 2 (PS2) genes cause the most common and aggressive form of familial Alzheimer's disease. Although PS1 function and dysfunction have beenContinue Reading
  • Vinciane Gaussin, Tom van de Putte, +5 authors Michael D. Schneider
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2002 (First Publication: 5 March 2002)
  • Receptors for bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGFbeta) superfamily, are persistently expressed during cardiac development, yet mice lacking type IIContinue Reading
  • Saskia Lippens, Mark Kockx, +9 authors Wim Declercq
  • Medicine, Biology
  • Cell Death and Differentiation
  • 2000 (First Publication: 1 December 2000)
  • The epidermis is a stratified squamous epithelium in which keratinocytes progressively undergo terminal differentiation towards the skin surface leading to programmed cell death. In this respect weContinue Reading
  • Rui M Monteiro, Susana M. Chuva de Sousa Lopes, Monika Bialecka, Sophie de Boer, An Zwijsen, Christine L Mummery
  • Medicine, Biology
  • Genesis
  • 2008 (First Publication: 1 July 2008)
  • SUMMARY Bone morphogenetic protein (BMP) signaling is a key pathway in the patterning and development of organisms as diverse as fruit fly and humans. However, the determination of net BMP signaling,Continue Reading
  • Tilman Borggrefe, Matthias Lauth, An Zwijsen, Danny Huylebroeck, Franz Oswald, Benedetto Daniele Giaimo
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2016 (First Publication: 1 February 2016)
  • Notch signaling is a highly conserved signal transduction pathway that regulates stem cell maintenance and differentiation in several organ systems. Upon activation, the Notch receptor isContinue Reading