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INTRODUCTION Rheumatoid arthritis (RA) is a complex and clinically heterogeneous autoimmune disease. Currently, the relationship between pathogenic molecular drivers of disease in RA and therapeutic response is poorly understood. METHODS We analyzed synovial tissue samples from two RA cohorts of 49 and 20 patients using a combination of global gene(More)
We present a complete and practical analytical model for the IEEE 802.11-based multi-hop wireless networks. The features of our model are that it first takes into account the realistic problems both from the physical and MAC (Media Access Control) layers in multi-hop wireless networks, including packet collisions, neighboring interference, hidden node(More)
To interpret pharmacokinetic (PK) data of biotherapeutics, it is critical to understand which drug species is being measured by the PK assay. For therapeutic antibodies, it is generally accepted that "free" circulating antibodies are the pharmacologically active form needed to determine the PK/pharmacodynamic (PD) relationship, safety margin calculations,(More)
Host cell proteins are manufacturing process-related impurities that may co-purify with the product despite extensive efforts to optimize the purification process. The risks associated with these impurities can vary and may be patient and/or therapeutic dependent. Therefore, it is critical to monitor and control the levels of these impurities in products(More)
Described in the specifications of WAVE (Wireless Access in Vehicular Environments) standards, broadcast is the main traffic in vehicular networks when all vehicles monitor the control channel. In this paper, we show a simple Markov model to analyze the saturation throughput of control channel broadcast, our analysis reveals that existing IEEE 802.11p(More)
In wireless Ad hoc networks, using multi-channel technique on MAC layer to increase the network capacity is a promising technology. By extending the RTS/CTS mechanism of IEEE802.11 standard, we propose a busy tone-based multi-channel MAC protocol, which can significantly improve the network throughput by using busy tone to distribute the multiple channels(More)
This paper proposes a cross-layer adaptive cooperative MAC protocol (CAC-MAC) based on IEEE 802.11 DCF, which forms a complete Application-MAC-PHY layer framework. The main feature of CAC-MAC protocol is an adaptive selection of data transmission scheme according to packet length and instantaneous wireless channel conditions. Simulation results show that(More)
For analysis of the IEEE 802.11 distributed coordination function (DCF) under nonsaturated condition, one of the key assumptions commonly accepted is that given the offered load, the queue utilizations of contending nodes are the same for all transmitted packets. In practice, however, this assumption is not valid due to coupled queues effect. In this paper,(More)