Learn More
Although beta-amyloid (Aβ) deposition is a characteristic feature of Alzheimer's disease (AD), this pathology is commonly found in elderly normal controls (NC). The pattern of Aβ deposition as detected with Pittsburgh compound-B positron emission tomography (PIB-PET) imaging shows substantial spatial overlap with the default mode network (DMN), a group of(More)
OBJECTIVE To study the relationship between subjective cognition and the neuropathological hallmark of Alzheimer disease (AD), amyloid-β (Aβ) deposition, using carbon 11-labeled Pittsburgh Compound B (PiB) positron emission tomography in normal elderly individuals. DESIGN Cross-sectional analysis. SUBJECTS Forty-eight cognitively normal elderly subjects(More)
Although deposition of β-amyloid (Aβ), a pathological hallmark of Alzheimer's disease (AD), has also been reported in cognitively intact older people, its influence on brain structure and cognition during normal aging remains controversial. Using PET imaging with the radiotracer Pittsburgh compound B (PIB), structural MRI, and cognitive measures, we(More)
Although beta-amyloid (Ab) deposition is a characteristic feature of Alzheimer's disease (AD), this pathology is commonly found in elderly normal controls (NC). The pattern of Ab deposition as detected with Pittsburgh compound-B positron emission tomogra-phy (PIB-PET) imaging shows substantial spatial overlap with the default mode network (DMN), a group of(More)
We examined the relationships among intrinsic and extrinsic motivational orientations, achievement goals, and intelligence beliefs for 202 3 rd-through 8 th-grade children from K-8 schools. Analyses of age differences revealed substantial declines in intrinsic – but not extrinsic – motivation with increasing grade level. Intrinsic motivation was associated(More)
  • 1