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Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones
A simple hypothesis is presented which accounts for the majority of interactions observed in uninfected cells and suggests that PrPC organizes its molecular environment on account of its ability to bind to adhesion molecules harboring immunoglobulin-like domains, which in turn recognize oligomannose-bearing membrane proteins.
Investigating the effects of L- to D-amino acid substitution and deamidation on the activity and membrane interactions of antimicrobial peptide anoplin.
Interactions of antimicrobial peptide from C-terminus of myotoxin II with phospholipid mono- and bilayers.
Investigating the effect of a single glycine to alanine substitution on interactions of antimicrobial peptide latarcin 2a with a lipid membrane
- Grace Idiong, Amy Won, Annamaria Ruscito, Bonnie O. Leung, A. Hitchcock, A. Ianoul
- Biology, ChemistryEuropean Biophysics Journal
- 7 July 2011
Data indicate that decrease in the flexibility of ltc2a induced by the modification in the hinge region is likely to increase the peptide’s nonspecific interactions with zwitterionic cell membranes and potentially increase its toxicity against eukaryotic cells.
Effect of point mutations on the secondary structure and membrane interaction of antimicrobial peptide anoplin.
- Amy Won, S. Pripotnev, Annamaria Ruscito, A. Ianoul
- ChemistryThe journal of physical chemistry. B
- 2 February 2011
Anoplin (GLLKRIKTLL-NH(2)) is the smallest linear α-helical antimicrobial peptide found naturally to date. Antibacterial and hemolytic properties of anoplin depend strongly on physicochemical…
Imaging the membrane lytic activity of bioactive peptide latarcin 2a.
Imaging interactions of cationic antimicrobial peptides with model lipid monolayers using X-ray spectromicroscopy
- Bonnie O. Leung, A. Hitchcock, Amy Won, A. Ianoul, A. Scholl
- Physics, BiologyEuropean Biophysics Journal
- 5 March 2011
X-ray spectromicroscopy is shown to be a valuable quantitative tool for label-free imaging of lipid monolayers with antimicrobial peptides at a lateral spatial resolution below 80 nm.
The effects of L‐ to D‐isomerization and C‐terminus deamidation on the secondary structure of antimicrobial peptide Anoplin in aqueous and membrane mimicking environment
Interaction Between Lytic Peptide Latarcin 2A and Supported Lipid Bilayers Studied by in Situ Atomic Force Microscopy