We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1.8 x 10(-157)) and observed… (More)
Library writers wish to provide a guarantee not only that each procedure in the library performs correctly in isolation, but also that the procedures perform correctly when run in conjunction. To this end, we propose a method for static detection of deadlock in Java libraries. Our goal is to determine whether client code exists that may deadlock a library,… (More)
The computational bottleneck in a ray tracer using bounding volume hierarchies is often the ray intersection routine with axis-aligned bounding boxes. We describe a version of this routine that uses IEEE numerical properties to ensure that those tests are both robust and efficient. Sample source code is available online.
A memory abstraction is an abstraction layer between the program execution and the memory that provides a different " view " of a memory location depending on the execution context in which the memory access is made. Properly designed memory abstractions help ease the task of parallel programming by mitigating the complexity of synchronization or admitting… (More)
River otter (Lontra canadensis) use of Phragmites australis and density estimation using genetic techniques" (2011). River otters were extirpated in Nebraska in the early 1900's. In 1986 Nebraska Game and Parks Commission began reintroducing otters. In support of developing an otter management plan, I conducted research on two aspects of otter ecology in… (More)
BACKGROUND In academic medicine, women physicians lag behind their male counterparts in advancement and promotion to leadership positions. Lack of mentoring, among other factors, has been reported to contribute to this disparity. Peer mentoring has been reported as a successful alternative to the dyadic mentoring model for women interested in improving… (More)
Approved by: ______________________________ Advisor Date ii ACKNOWLEDGEMENTS I would like to thank Dr. Annmarie Cano for her time and dedication in the preparation of this thesis. Her support throughout this project was invaluable and was greatly appreciated. I would also like to thank the members of my thesis committee, Dr.
BioOne (www.bioone.org) is a nonprofit, online aggregation of core research in the biological, ecological, and environmental sciences. BioOne provides a sustainable online platform for over 170 journals and books published by nonprofit societies, associations, museums, institutions, and presses. Usage of BioOne content is strictly limited to personal,… (More)
The views and conclusions contained in this document are those of the author and should not be interpreted as representing the official policies, either expressed or implied, of any sponsoring institution, the U.S. government or any other entity. Abstract In many machine learning application domains obtaining labeled data is expensive but obtaining… (More)