Learn More
Regulation of CNS arousal is important for a wide variety of functions, including the initiation of all motivated behaviors. Usually studied with pharmacological or hormonal tools, CNS arousal can also be elevated by deep brain stimulation (DBS), in the human brain and in animals. The effectiveness of DBS is conventionally held to depend on pulse width,(More)
We report that mice with closed-head multiple traumatic brain injury (TBI) show a decrease in the motoric aspects of generalized arousal, as measured by automated, quantitative behavioral assays. Further, we found that temporally-patterned deep brain stimulation (DBS) can increase generalized arousal and spontaneous motor activity in this mouse model of(More)
In the present paper, we quantify, with a rigorous approach, the nature of motor activity in response to Deep Brain Stimulation (DBS), in the mouse. DBS is currently being used in the treatment of a broad range of diseases, but its underlying principles are still unclear. Because mouse movement involves rapidly repeated starting and stopping, one must(More)
  • 1