Amy M. Jonk

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The intertwined epidemics of obesity and related disorders such as hypertension, insulin resistance, type 2 diabetes, and subsequent cardiovascular disease pose a major public health challenge. To meet this challenge, we must understand the interplay between adipose tissue and the vasculature. Microvascular dysfunction is important not only in the(More)
Type 2 diabetes and its major risk factor, obesity, are a growing burden for public health. The mechanisms that connect obesity and its related disorders, such as insulin resistance, type 2 diabetes, and hypertension, are still undefined. Microvascular dysfunction may be a pathophysi-ologic link between insulin resistance and hypertension in obesity. Many(More)
1 O besity is associated with insulin resistance, hypertension, cardio-vascular disease, and type 2 diabetes (1), but the mechanisms underlying these associations are incompletely understood. This article reviews and adds original data (i.e., in the postprandial state) to the evidence for microvascular dysfunction, including impairment of insulin-stimulated(More)
Facilitated hexose transporter proteins may have clusters of hydrophobic residues lining the exofacial entrance to their pores, which act as substrate selectivity filters. Glucose is a signal that is detected at several anatomical sites and activates neuronal circuits involved in the control of glucose and energy homeostasis. This review looks at the(More)
adapted from Microvascular dysfunction: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension. Opening remarks This thesis describes the studies performed at the VU medical center during my PhD project. It is the latest in a line of projects testing our group's main hypothesis: the microvasculature as a pivot at(More)
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