Amy L Penhall

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Paravalvular regurgitation (PVR) following transcatheter aortic valve replacement is a known complication associated with poorer outcomes. This article discusses the current techniques for assessing the severity of PVR, including angiography, hemodynamics, MRI, and echocardiography. The strengths and pitfalls of each modality are reviewed.
OBJECTIVES There remains a paucity of mechanistic data on the effect of transcatheter aortic valve implantation (TAVI) on early left and right ventricular function and quantitative aortic valve regurgitation. We sought to assess and compare the early effects on myocardial function and aortic valve hemodynamics of TAVI and aortic valve replacement (AVR)(More)
PURPOSE Right ventricular (RV) systolic function as measured by right ventricular ejection fraction (RVEF) has long been recognized as an important predictor of outcome in heart failure patients. The echocardiographic measurement of RV volumes and RVEF is challenging, however, owing to the unique geometry of the right ventricle. Several nonvolumetric(More)
AIMS The aims of this study were (1) to evaluate the relationship between novel two-dimensional transthoracic indices of left atrial (LA) mechanical function (speckle-tracking- and tissue Doppler-derived parameters), conventional indices (A-wave peak velocity and velocity-time integral, and A' velocity), and transoesophageal echocardiographic parameters (LA(More)
Methods Thirty six breast cancer patients undergoing chemotherapy (26 anthracyline, 10 tranztumab) underwent serial CMR imaging (for LV and RV volumes/ejection fraction) and echocardiography for tricuspid annular systolic plane excursion (TAPSE) at baseline, 1, 3 and 12 months. RV impairment following chemotherapy was defined as an reduction of CMR RVEF(More)
Background Myocardial dysfunction is a recognized toxicity of anthracycline (A) and herceptin (H) chemotherapy. Whilst there is much current focus on the incidence and magnitude of myocardial dysfunction following the A/H regimen, whether these changes are mediated by reversible or irreversible myocardial injury remains unknown. We sought to determine rates(More)
Methods 29 chemonaive patients with breast cancer (early stage and metastatic), underwent serial cardiovascular magnetic resonance imaging (for LV volumes/ejection fraction, myocardial oedema and necrosis), advanced echocardiography (for LV strain in addition to standard measurements of LV diastolic function), pro brain natriuretic peptide (pro-BNP) and(More)
Introduction Right ventricular ejection fraction (RVEF) is an important predictor of outcome in heart failure patients. Although cardiac magnetic resonance (CMR) assessment of RV function is considered gold standard and echocardiographic measurement of RVEF is challenging due to its unique geometry; CMR still has limited availability in the wider community.(More)
We are reporting a case of 66 year-old man who presented to a regional hospital with sudden onset of inter-scapular pain, radiating to anterior chest. Initial assessment was unremarkable except for high blood pressure and computed tomography (CT) of chest showing an intramural haematoma in the thoracic descending aorta. He was transferred to our institution(More)
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