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BACKGROUND Communicable disease outbreaks of novel or existing pathogens threaten human health around the globe. It would be desirable to rapidly characterize such outbreaks and develop accurate projections of their duration and cumulative size even when limited preliminary data are available. Here we develop a mathematical model to aid public health(More)
823 W hereas different materials respond to stress by hugely different amounts, Poisson's ratio, ν, is contained within narrow numerical bounds, embracing the mechanical properties of every isotropic material, from the most incompressible to the most extendable, from the softest solid to the strongest liquid. Convoluting mechanical response at the atomic(More)
Amorphous metallic alloys, relative newcomers to the world of glasses, have properties that are unusual for solid metals. The metallic glasses, which exist in a very wide variety of compositions, combine fundamental interest with practical applications. They also serve as precursors for exciting new nanocrystalline materials. Their magnetic (soft and hard)(More)
BACKGROUND The world is currently confronting the first influenza pandemic of the 21(st) century. Influenza vaccination is an effective preventive measure, but the unique epidemiological features of swine-origin influenza A (H1N1) (pH1N1) introduce uncertainty as to the best strategy for prioritization of vaccine allocation. We sought to determine optimal(More)
BACKGROUND Much remains unknown about the effect of timing and prioritization of vaccination against pandemic (pH1N1) 2009 virus on health outcomes. We adapted a city-level contact network model to study different campaigns on influenza morbidity and mortality. METHODS We modeled different distribution strategies initiated between July and November 2009(More)
OBJECTIVES During the first wave of the 2009 influenza pH1N1, disease burden was distributed in a geographically heterogeneous fashion. It was particularly high in some remote and isolated Canadian communities when compared with urban centres. We sought to estimate the transmissibility (the basic reproduction number) of pH1N1 strain in some remote and(More)
  • S V Ketov, Y H Sun, S Nachum, Z Lu, A Checchi, A R Beraldin +5 others
  • 2015
When a spatially uniform temperature change is imposed on a solid with more than one phase, or on a polycrystal of a single, non-cubic phase (showing anisotropic expansion-contraction), the resulting thermal strain is inhomogeneous (non-affine). Thermal cycling induces internal stresses, leading to structural and property changes that are usually(More)
INTRODUCTION Emerging data suggest that receipt of the seasonal influenza vaccine may be associated with an enhanced risk of infection with pandemic (H1N1) 2009 (pH1N1). We sought to evaluate different seasonal vaccination strategies during a pandemic in the presence of varying levels of pH1N1 infection risk following seasonal influenza vaccine receipt. (More)
BACKGROUND The prevalence and severity of the 2009 H1N1 pandemic appeared to vary significantly across populations and geographic regions. We sought to investigate the variability in transmissibility of H1N1 pandemic in different health regions (including urban centres and remote, isolated communities) in the province of Manitoba, Canada. METHODS The(More)
BACKGROUND Due to the lack of timely access to resources for critical care, strategic use of antiviral drugs is crucial for mitigating the impact of novel influenza viruses with pandemic potential in remote and isolated communities. We sought to evaluate the effect of antiviral treatment and prophylaxis of close contacts in a Canadian remote northern(More)