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Huntington's disease (HD) is an inherited progressive neurological disorder for which there is no effective therapy. It is caused by a CAG/polyglutamine repeat expansion that leads to abnormal protein aggregation and deposition in the brain. Several compounds have been shown to disrupt the aggregation process in vitro, including a number of benzothiazoles.(More)
Endorepellin, the COOH-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits several aspects of angiogenesis. We provide evidence for a novel biological axis that links a soluble fragment of perlecan protein core to the major cell surface receptor for collagen I, alpha2beta1 integrin, and provide an initial investigation of the(More)
The Control anti-avb3 micrograph in the original version of Fig. 5 A was a duplicate of the Control micrograph in Fig. 6 A. The authors have indicated that this was due to a clerical error during figure preparation. A corrected version of Fig. 5 A is shown below. In addition, the original version of Fig. 9 B showed a composite panel for Total Erk1/Erk2 that(More)
Attention deficit/hyperactivity disorder (ADHD) is a common and impairing psychiatric condition, affecting significant numbers of children and adolescents. General psychiatrists serve, both by choice and out of necessity, in the assessment and treatment of children and adolescents who have ADHD and in the education of patients and their families. For many(More)
BACKGROUND As people live longer, there is increasing potential for mental disorders to interfere with testamentary distribution and render older people more vulnerable to "undue influence" when they are making a will. Accordingly, clinicians dealing with the mental disorders of older people will be called upon increasingly to advise the courts about a(More)
  • A Barker
  • 2004
The way that mental health care for older people is developing in the UK is being shaped by a number of factors. These include demographic shifts, changes in the general population's attitudes to health, alterations in professional practice, governmental policy, and medical and technological advances. This article summarises some key aspects of these(More)