Amy Kaestner

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Claustrophobia, the well-known fear of being trapped in narrow/closed spaces, is often considered a conditioned response to traumatic experience. Surprisingly, we found that mutations affecting a single gene, encoding a stress-regulated neuronal protein, can cause claustrophobia. Gpm6a-deficient mice develop normally and lack obvious behavioral(More)
Genotype-phenotype correlations of common monogenic diseases revealed that the degree of deviation of mutant genes from wild-type structure and function often predicts disease onset and severity. In complex disorders such as schizophrenia, the overall genetic risk is still often >50% but genotype-phenotype relationships are unclear. Recent genome-wide(More)
Many stroke survivors experience somatosensory deficits and there is currently no “gold standard” reliable standardized assessment commonly used by clinicians in the United States. In the present study, the authors modified the Nottingham Sensory Assessment (NSA) into a U.S. version to provide therapists with a standardized multimodal sensory assessment for(More)
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