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Nocathiacin analogs: Synthesis and antibacterial activity of novel water-soluble amides.
Novel water-soluble amide analogs were synthesized from nocathiacin I (1) through the formation of the carboxylic acid intermediate followed by coupling to primary or secondary amines. SeveralExpand
Synthesis and antibacterial activity of novel water-soluble nocathiacin analogs.
TLDR
Semi-synthetic water-soluble analogs were synthesized from nocathiacin I through the formation of a versatile intermediate nocATHiacin amine 5, and subsequent transformation via reductive amination, acylation or urea formation, showing much improved aqueous solubility over 1. Expand
Conversion of nocathiacin I to nocathiacin acid by a mild and selective cleavage of dehydroalanine.
TLDR
Two equipotent water-soluble amide analogues of nocathiacin I were readily prepared from this important and versatile carboxylic acid intermediate under mild peptide coupling conditions, useful for chemical derivatization of complex natural products that contain C-terminal dehydroalanine. Expand
Minimal Evidence for a Secondary Loss of Strength After an Acute Muscle Injury: A Systematic Review and Meta-Analysis
TLDR
The findings do not support the presence of a secondary loss of strength following an acute muscle injury, and strongly suggest that strength, on average, recovers steadily over the first 3 days post-injury. Expand
Clinical Measures Predicting Knee Extensor Muscle Activation During a Maximal Voluntary Isometric Contraction
TLDR
The inability to maximally activate the knee extensors in the absence of frank tissue damage can alter athletic performance, which often relies on optimal contraction of this lower-extremity muscle group. Expand