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2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung
BackgroundPseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like"Expand
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Analysis of biogenic volatile organic compounds in human health and disease
The analysis of volatile biomarkers of disease in breath is attractive because breath analysis is non-invasive and quick, and allows for repeated sampling. Challenges faced in the development ofExpand
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Developments in novel breath tests for bacterial and fungal pulmonary infection.
PURPOSE OF REVIEW Breath testing has developed over the last 20 years. New techniques that can identify fingerprints for specific diseases and specific markers of respiratory pathogens have beenExpand
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Novel diagnostics: progress toward a breath test for invasive Aspergillus fumigatus.
In this paper we will briefly review some of the possible techniques for the development of a breath test for aspergillosis and describe progress made toward validating 2-Pentyl furan (2PF) as aExpand
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Quantification of hydrogen cyanide (HCN) in breath using selected ion flow tube mass spectrometry--HCN is not a biomarker of Pseudomonas in chronic suppurative lung disease.
Hydrogen cyanide (HCN) in exhaled breath has been proposed as a biomarker for airway inflammation, and also a marker of the presence in the airways of specific organisms, especially PseudomonasExpand
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Potential sources of 2-aminoacetophenone to confound the Pseudomonas aeruginosa breath test, including analysis of a food challenge study.
2-Aminoacetophenone can be detected in the breath of Pseudomonas aeruginosa colonized cystic fibrosis patients; however, low levels were also detected in a small proportion of healthy subjects. ItExpand
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Assessment of potential causes of falsely positive Mycobacterium tuberculosis breath test.
A suite of volatiles have previously been identified as specific markers of Mycobacterium tuberculosis metabolism in vitro. These markers - methyl phenylacetate, methyl p-anisate, methyl nicotinate,Expand
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Determining the limits and confounders for the 2-pentyl furan breath test by gas chromatography/mass spectrometry.
Aspergillus fumigatus produces 2-pentyl furan (2-PF), a volatile compound not produced by many other pathogens or normal human metabolism. 2-Pentyl furan has been detected in the breath of patientsExpand
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Validating a breath collection and analysis system for the new tuberculosis breath test.
Mycobacterium tuberculosis releases four volatile compounds, methyl phenyl-acetate, methyl nicotinate, methyl p-anisate and o-phenylanisole, some of which we have previously been reported to beExpand
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Volatile Organic Compounds: Upcoming Role in Diagnosis of Invasive Mould Infections
Purpose of ReviewBreath testing for fungal respiratory infections has great promise as samples can be obtained by non-invasive, repeatable techniques that can be done on a wide range of patientsExpand
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