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Patient and technique survival on peritoneal dialysis in the United States: Evaluation in large incident cohorts. Secular trends in dialysis require a frequent re-examination of outcomes in patients on renal replacement modalities. We examined three large cohorts of patients initiating peritoneal dialysis (PD) in 1999, 2000, and 2001 (total of > 30,000(More)
CONTEXT Irritable bowel syndrome (IBS) is a common functional bowel disorder for which there is no reliable medical treatment. OBJECTIVE To determine whether Chinese herbal medicine (CHM) is of any benefit in the treatment of IBS. DESIGN Randomized, double-blind, placebo-controlled trial conducted during 1996 through 1997. SETTING Patients were(More)
OBJECTIVE To develop and validate the Premenstrual Symptoms Impact Survey (PMSIS), a brief web-based instrument for evaluating the impact of premenstrual symptoms on health-related quality of life (HRQOL). METHODS An item bank of 68 questions was administered to a nationally representative sample of 971 women using the web, aged 18-45, who experienced(More)
OBJECTIVE To compare healthcare resource utilization, costs, and treatment adherence associated with dasatinib versus nilotinib treatment as second-line therapies in chronic myeloid leukemia (CML) patients. METHODS Two large retrospective claims databases (01/1999-06/2009) were combined to identify CML patients (ICD-9 code 205.1x) who received one or more(More)
BACKGROUND Patients with chronic myeloid leukemia (CML) who do not adhere to treatment may experience suboptimal outcomes. OBJECTIVE To examine the association between adherence with imatinib and direct healthcare costs and resource utilization in a large group of privately insured CML patients. PATIENTS AND METHODS CML patients under age 65 were(More)
Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair(More)
e15115 Background: A Phase III clinical trial ( NCT00321620 ) recently demonstrated that denosumab delayed time to 1st skeletal-related event (SRE) and subsequent SREs longer than zoledronic acid (ZA), but showed no difference in either survival or disease progression between the two products. The objective of this study was to conduct an economic(More)
This study was conducted to evaluate the treatment outcomes associated with common second-line targeted therapies given after first-line sunitinib for metastatic renal cell carcinoma (mRCC). The sample comprised patients with mRCC (n = 257) who were receiving second-line everolimus, sorafenib, or temsirolimus between April 1, 2008, and February 29, 2011,(More)
BACKGROUND The number of end-stage renal disease (ESRD) enrollees and Medicare expenditures have increased dramatically. Pathways and associated Medicare expenditures in ESRD treatment need to be examined to potentially improve the efficiency of care. METHODS This study examines the impact of initial dialysis modality choice and subsequent modality(More)